10/11/06
From Biolk483
Enzymes
- cofactors --> help with catalysis
- most are organic ("coenzymes") --> zinc is NOT organic
- holoenzyme --> enzyme + cofactors
9 Types of Coenzymes
1) Pyridoxal Phosphate
- aspartate transaminase --> trans-schiffization (?)
2) Nicotinamide Adenine Dinucleotide (NAD) --> involved in redox reactions
- functions in the complementary reduction reaction of an oxidation reaction
- also functions in the oxidation of alcohol
3) Flavin Mononucleotide (Flavin Adenine Dinucleotide="FAD")
- vitamin B2
- involved in redox reactions
- assists succinate dehydrogenase turn succinate into fumarate
4) Thiamine
- vitamin B1
- allows reactions to start
- connects glycolysis to kreb cycle
- has an acidic carbon which is very rare
5) Coenzyme A
- vitamin B3
- has sulfur group and an ADP
- ex. acetyl CoA
6) Biotin
- involved in carboxylation reactions (ex. pyruvate --> oxaloacetate)
7) S-Adenocyl Methionine
- methylating agent (methylates phospholipids)
8) tetrahydrofolate (folic acid)
- involved in 1 carbon reactions
- not really all that important... (that's what he said!)
9) Cobalamine
- vitamin B12
- involved in complex rearrangements
- he said this wasn't super important either...
((I'm sorry if there are any mistakes!! This is my first time uploading any notes to this site, and I'm having issues. I just wanted to help some people out because these notes have definitely helped me study for the first exam!!))
