Nucleus basalis

From Psy3242

Definition

the gray matter of the substantia innominata of the forebrain that consists mostly of cholinergic neurons [1]

Clinical significance

In Parkinson and Alzheimer diseases the nucleus undergoes degeneration. A decrease in acetylcholine production is seen in Alzheimer's disease, Lewy body dementia and some Parkinson Disease patients showing abnormal brain function, leading to a general decrease of mental capacity and learning.