We should tell the Alliance.
From Create Your Own Story
YOU: If human Colonies are disappearing, then this is an issue for the Alliance. We should contact them.
THE ILLUSIVE MAN: I'm feeling a little maligned here. Why is siding with the Alliance the Paragon option? I do everything I can to help humanity, and then the game just labels me as Renegade material.
YOU: Someone has to be option B.
THE ILLUSIVE MAN: I guess. The Alliance won't do a thing for these colonies, though- we're on our own. If you want to stop the Reapers, you're going to have to rely on my Intel.
THE ILLUSIVE MAN: Speaking of intel, it's convenient that you came out of stasis early, actually, Commander, because I've just got word that there's a human colony being attacked RIGHT THIS VERY SECOND.
YOU: Wow. Good timing.
THE ILLUSIVE MAN : You got that right. (Stubbing out cigar, leaning forward) I'm going to be sending you to Freedoms Progress. They just got abducted five seconds ago, so you should get there right before anyone else. I want you to find who's kidnapping these colonist. What's their modus operandi, what's their motivations. Is it actually the Reapers, or is it just slavers or something and I just wasted a billion credits bringing you back. That sort of thing. Find that out, Shepard, and we'll talk again.
THE ILLUSIVE MAN: There's a shuttle waiting for you, Commander. Good to finally talk to you.
The HOLOGRAM PROJECTOR ROOM swims back into view. You are alone.
Do you: