OBGYN - Family Planning

From Iusmicm

Contents

[edit] Contraception

[edit] Objectives

  • Review basic statistics concerning population growth and pregnancy rates
  • Review basic contraceptive options
  • Review sterilization options

[edit] World population growth

  • Population growth is logarithmic since around 1950.
  • The world is growing at about 1.8% each year.
  • Every minute, a woman dies of pregnancy / childbirth complications.
    • 99% of these deaths occur in developing countries.
    • 1 million children left motherless.
  • Maternal mortality rates vary from 1/7 (Niger) to 1/17.4k (Sweden).


  • Birth control is controversial for three reasons:
    • Personal issues
    • Religious issues
    • Political issues

[edit] Counseling

  • Counseling about contraception is important.
  • 10% of women don't use birth control.
  • 53% of unintended pregnancies result from these 10% of women (who aren't using birth control).
  • Abortions are highest in those less than 15yo.
    • Abortions decrease as the woman ages to 30-34.
    • Abortions increase again from 35 and up.


  • In 2002 there were 6.4 million pregnancies.
    • 51% were intended
    • 49% were unintended
      • 22% were unintended births
      • 20% were elective abortions
      • 7% were fetal losses


  • Of unintended pregnancies that proceed to live births,
    • 1/4 are "unwanted"
    • 3/4 are "mistimed"


  • Of unintended pregnancies that proceed to live births, about 40% of women were using contraceptives at the time of conception.


[edit] Abortion rates

  • The United States of America aborts 22.9 of each 1000 fetuses.
  • Australia: 22.2 / 1000

[edit] Birth Controls

  • There are two categories of birth control: contraception (prevent conception) and implant preventors.
  • Contraceptions include:
    • OCPs
    • Norplant
    • Depo-Provera
    • Condoms
    • Diaphragm
    • Foam
    • Rhythm
    • IUDs
  • Implant preventors include IUDs and morning after pills.


  • The most commonly used birth control is tubal ligation making up nearly 50% of contraception use in "non-developed" countries.

[edit] Barrier methods

  • Barrier methods include: spermacides, condoms, diaphragms / cervical caps, and sponges


  • Spermacides
    • The active ingredient of spermacides is nonoxynol 9 or actoxynol-3.
      • Nonoxynol and actoxynol disrupt the spermatic cell membrane.
    • The failure rate of spermacides is 15-35%.
    • Patient compliance is generally high.


  • Condoms
    • Male condom failure rate is 5-8% (slippage / breakage) or 5-15%
    • Female condom failure rate is 3% (slippage / breakage) or 5-15%
    • Mechanism of action is to physically block sperm.


  • Diaphragms
    • Mechanism of action is to physically block sperm from gaining access to upper reproductive tract (uterus and fallopian tube.
    • Diaphragms can also hold spermicide.
    • Device must be inserted 1 hour before intercourse.
    • Diaphragm must remain in place for 6-8 hours post-coitus.
    • Failure rate is 10-25%
    • Benefits include:
      • Some protection agains STDs
      • Effective immediately
      • Does not affect breast feeding
      • Does not interfere with intercourse (can be inserted up to 6 hours pre-coitus).
      • No health risks.
      • No systemic side effects.
    • Contraindications include:
      • Hx of toxic shock syndrome
      • Allergy to rubber
      • Allergy to spermicides
      • Repeat UTIs
      • Uterine prolapse
      • Vaginal stenosis
      • Genital anomalies
    • Patient compliance is difficult


  • The sponge
    • Mechanism: contains spermicide
    • Benefits: small, disposible, works for 24 hours (regardless of coitus count)
    • Reintroduced to market in 2009.
    • Failure rate: 26-40%


[edit] Hormonal contraceptives

  • Hormonal contraceptives come as oral pills, as injectables, and as an intravaginal ring or a supradermal patch.
  • Injectable contraceptives include:
**Combined injectible contraceptives (CICs)
    • Depo-provera
    • Norplant
    • Implanon

[edit] Oral contraceptive pills

  • Failure rate is <1%
  • OCPs can be progesterone only or a combination of estrogen and progesterone (combined oral contraceptives; COCs).


  • Oral contraceptive pills are taken 21 days with 7 days of placebo or no pill.
  • Combined oral contraceptives come in three types depending on their phase:
    • Monophasic: all 21 pills, all of which have some amount of estrogen / progesterone (E/P)
    • Biphasic: 21 active pills, 2 different combinations of E/P
    • Triphasic: 21 active pills, 3 different combinations of E/P


[edit] OCP mechanism of action
  • Presence of progesterone decreases FSH and LH levels, including the LH surge.
  • Without the LH surge, ovulation does not occur.
  • Furthermore the endometrial lining is thinner which makes implantation less likely.
  • The cervical lining is thickened which prevents spermatic penetration to the upper reproductive tract.


[edit] OCP Benefits
  • Contraceptive benefits of OCP:
    • Highly effective (failure rate <1%)
    • Effective immediately if started by day 7 of menstrual cycle.
    • Pelvic examination not required to initiate use.
    • OCPs do not interfere with intercourse.
    • Few side effects.
    • Convenient and easy.
    • Client can stop use at any time.
    • Can be provided by trained medical staff.


  • Non-contraceptive benefits of OCP:
    • Decrease menstrual flow.
    • Decrease menstrual cramps.
    • Improve anemia (?).
    • Protect against ovarian and endometrial cancer.
    • Decrease bening breast disease and ovarian cysts.
    • Prevent ectopic pregnancy.
    • Protect against some causes of pelvic inflammatory disease.


[edit] OCP Effectiveness
  • Perfect use is what is tested but then there is actual or typical use.
    • OCP (combined versions) are 97% effective when taken perfectly.
    • OCP (combined versions) are 92% effective upon actual use.
  • 10 million women are taking OCP; therefore each 1% decrease in effectiveness yields 100k unintended pregnancies
    • 8% decrease simply from perfect use to typical use.


[edit] OCP Contraindications
  • Absolute contraindications include:
    • History of vascular disease: pulmonary embolism, deep vein thrombosis, coronary vascular atherosclerosis
    • Systemic disease: lupus, chronic hypertension, liver disease, hypercholesterolemia, migraine headaches with auras.


  • Relative contraindications include:
    • Tobacco use
    • >35 yo
    • Depression
    • Seizures without auras


[edit] Injectables

  • Mechanism of action:
    • Suppress ovulation
    • Thicken cervical mucosa
    • Thin endometrium


  • Types of injectable birth controls include:
    • CICs (like OCPs)
    • Depo-Provera
    • Norplant
    • Implantation


  • Failure rate for injectables:
    • CICs: 0.1-1%
    • Depo-Provera: 0.1-0.6%
    • Norplant / Implanton: 0.2-0.6%


  • Injectable limitations
    • Side effects include: nausea, dizziness, breast tenderness, headaches, spotting, light bleeding
    • Effectiveness lowered in combination with other drugs
    • Can delay return to fertility
    • Serious side effects are possible
    • Do not protect against STDs
    • Change the menstrual bleeding pattern
    • User-dependent; that is, the client must return every 30 days.


  • Injectable benefits:
    • Highly effective
    • Effective immediately
    • Pelvic examination not required before use (as with OCPs)
    • Do not interfere with intercourse
    • "Few side effects" (though more than OCPs)
    • Can be provided by trained medical staff
    • No supplies needed by the client

[edit] Contraceptive Ring

  • NuvaRing
  • 2 inches in diameter
  • 120mg etonogestrel, 15mg ethinyl estradiol
  • As effective as OCP
  • One ring / cycle
    • 3 weeks in the vagina, 1 week without
  • Not a barrier!

[edit] Contraceptive patch

  • Ortho Evra
  • 150 mg norelgestromin, 20mg ethinyl estradiol
  • As effective as OCPs
  • Better compliance (90%) than OCPs (77%)
  • Three patches / cycle, one each week for three weeks; 1 week without patch.

[edit] Intra-uterine Devices (IUD)

  • Failure rate of 0.2-3%


  • Mechanism of action can be contraceptive or abortive.
    • Interferes with sperm ability to travel through uterine cavity.
    • Thickens the cervical mucus.
    • Intereferes with reproductive process before ova can reach the uterine cavity.
    • Modifies the endometrial lining to decrease implantation.


  • IUD advantages:
    • Non-hormonal
    • Failure rate of only 0.2-3%
    • Effective immediately
    • Long-term (up to 10 years)
    • Does not interfere with intercourse
    • Immediate return to fertility upon removal
    • Does not affect breast feeding


  • IUD contraindications
    • Pregnancy (risk of ectopic pregnancy)
    • Unexplained vaginal bleeding
    • PID
    • Purulent discharge
    • Distorted uterine cavity
    • Malignment trophoblast disease
    • Pelvic TB
    • Genital tract cancer
    • GU tract infection


[edit] Sterilization

  • Sterilization is the most common method of birth control among married couples.
  • Sterilization is the most common method of birth control globally.
  • Only 1% regret sterilization.
  • Failure rate is 1-2% over 10 years


  • 10% of couples choosing sterilization choose vasectomy
    • Failure rate of vasectomy is 0.1%

[edit] Miscellaneous

  • Laction is a good birth control, too.
    • Lactation failure rate is 2% for the first 6th months.
    • Mechanism of action is disruption of GnRH release because of frequent, intense suckling at the nipple.
    • Disrupted GnRH means disrupted LH / FSH release which means no ovulation.
    • Limitations
      • Does not protect against STDs
      • No longer effective once menses begin again
      • Hard to maintain because of social aspects of breast feeding


  • NFP / Rhythm birth control
    • Requires that couples be highly motivated to maintain compliance.
    • Failure rate is 1-45%.
    • NFP can be monitored by several methods: calendar, basal body temperature (BBT), cervical mucus method (Billings), or symptothermal (BBT + Billings)


  • Withdrawal method birth control
    • One of the oldest methods.
    • Failure rate is 20-25%

[edit] Emergency Contraception

  • "Morning after" pill
    • Debates over whether it is a contraceptive or an abortifacent
  • IUD
    • Abortifacent

[edit] Morning After Pill

  • There are two medicinal methods for emergency birth control:
    • The Yuzpe method is 2 tablets of 0.25 mg loveonogestrol at 0 and 12 hours.
    • The Plan B method is 1 tablet of 0.75 mg levonorgestrel at 0 and 12 hours.
      • Plan B has less n / v
      • Plan B is more effective


[edit] Male alternatives

  • Traditional methods
    • Periodic Abstinence
      • High contraceptive efficacy if rules followed perfectly
      • Typical 1st year failure rate: 20%
      • Limited Acceptability: low reliability, inflexibility
    • Non-Vaginal Ejaculation
      • Historically the major pre-industrial method of family planning
      • Limited Reliability: requires skill and self-control
      • Typical 1st year failure rate: 20%
    • Vasectomy
      • Relative Contraindications: bleeding disorders, allergy to anesthestics, scrotal pathology
      • Excises a segment of vas deferens
      • Failure Rate: 0.1% - wait as long as three months
  • Condom


  • Modern methods
    • Vas Occlusion
      • "reversible vasectomy"
      • Lower efficacy than true vasectomy
    • Heating
      • Principle: brief elevations of testicular temperature suppresses spermatogenesis
      • Concept: tight scrotal support – remains to be clinically proven
    • Immunocontraception
      • Sperm Vaccination – men and women
    • Chemical (non-hormonal)
      • Target the rapidly proliferating germinal epithelium with drugs, heat, ionising radiation, thereby disrupting mitosis and/or meiosis


  • Hormonal
    • WHO Studies utilized weekly testosterone enanthate injections
      • Provides both gonadotropin suppression and androgen replacement
      • Contraceptive Failure Rate of about 8%
      • Adverse Affects: cardiovascular & prostatic diseases, mood changes
    • Other Studies looked at Androgen Combination regimens:
      • Non-androgens (estrogen, progestins) to suppress gonadotropins with testosterone
      • GnRH Blockades with testosterone add-back
      • FSH Blockades



[edit] Family Planning

  • Historically:
    • Pubarche occured in the upper teens
    • Breastfed 3-4 yrs caused amennorhea which is an excellent, natural birth control
    • Only 50% reached the teens (reproductive age)
      • Disease
      • Starvation
  • Now:
    • 7 Billion and counting


  • Adolescent Pregnancy:
    • Pregnancy rate is decreasing
    • Birth rate is decreasing
    • Abortion rate is decreasing
    • Adolescent pregnancy in general is decreasing.
    • Trends are across white, Hispanic, and African American races
    • US still has very high teen pregnancy rate compared to other countries


  • Incidence of unintended pregnancy is similar with and without contraception but the risk is much higher for those without.
  • Cost of unintended pregnancy:
    • birth, abortions, fetal loss.
    • 5 billion dollars.

[edit] Contraception Counseling

  • Should be part of any exam!
  • Process / questions:
    • How important is it to you to avoid pregnancy now?
    • What would you do if you became pregnant now?
    • What is your desired family size?
    • What is your intended timing for pregnancy?
    • Are there health issues that you need to address before you become pregnant?


  • Lactation is effective for 6 months.
    • Must be exclusively breast feeding.


  • 5-year cost of contraceptive methods
    • Includes cost of unintended pregnancy.
    • Cheapest -> expensive
      • Copper IUD ($540)
      • Vasectomy
      • Injectable
      • OCP ($1784)
      • Condom ($2424)
      • Ligation
      • Withdrawal
      • Periodic abstinence ($3450)
      • Female condom
      • Sponge
      • Cervical cap ($5730)
      • None ($14663)

[edit] Types

[edit] Barrier methods

  • Keeps spermatozoa from meeting egg


  • Chemical (foams, spermicides)
    • Can come in sponges, films, or creams


  • Physical (condoms)
    • Oldest were sheep skin
    • Female is expensive
    • Getting better at having adolescent males use them.
    • They protect from STDs!


  • Diaphragm
    • Made by one company
    • Requires office visit for fitting
    • Catches sperm
    • Fits behind pubic symphisis and behind the cervix
    • Pressure on ureter increases risk for UTI.
    • Can use diaphragm to to catch blood of menses, too.
      • As long as no hx of toxic shock syndrome

[edit] Hormonal methods

  • The pill
    • OCP = oral contraceptive pills
    • Pill, patch, ring


  • Injection
    • Every 3 months
    • Slightly more effective
    • Weight gain common, irregular bleeding
      • Results in cessation
    • Cessation results in decreased effectiveness.
    • Can be used to treat heavy bleeding too.


  • Implant
    • Norplant had silicon and lawsuits caused it to be taken off the market.
    • Implanon = Nexplanon
      • A source of estrogen (etonogestrel)

[edit] Mechanism of Hormonal contraceptions

  • Ovulation is presented by providing feedback with progesterone to decrease LH surge.
  • Progesterone:
    • Inhibits LH surge such that ovulation is decreased.
    • Makes cervical mucus thick to inhibit sperm motility
    • Smooth muscle relaxant to decrease transport of sperm in the fallopian tube (which has SM and cilia helping to move the sperm toward the egg)
    • Decreases glycogen stores in the endometrium such that ovum is less likely to survive / implant
  • Estrogen:
    • decreases FSH such that there is little follicle development
    • increases progesterone receptors so as to potentiate the effect of the progesterone


  • Bonus benefits
    • Decreased ectopic preg
    • Regulates menses
      • Good tx for irregular menses
    • Decrease PID / salpingitis risk
      • Good tx with gonorrhea and chlamydia
    • Less acne / hirsuitism
      • Because estrogen increases sex hormone binding globulin (SHBG) at the liver
      • Binds testosterone and decreases androgenic effect
    • Decreased androgen production, too
      • Because test is made in ovary and FSH is decreased
    • Decreased benign breast disease
      • Recall however that benign breast fibrosis has no increased risk for cancer
    • Decreased risk of endometiral cancer
      • 50% risk
      • Last for 15 years!
    • Decreased risk of ovarian cancer
      • 30%
      • 30 years of protection

[edit] IUD

  • Very good compliance
  • Good for long term use
  • Two types in US
    • LNG IUS
    • Copper T (380 A)


  • Mechanism of action
    • Impairs sperm motility through uterus via copper.
    • Impairs sperm motility via prosterone's increased thickness effect.
    • Inflammatory environment reaction in the uterus makes hostile to sperm.


  • Very low failure rate: 0.2-0.8%


  • Contraindications:
    • Recent PID
    • Suspicion of genital cancer
    • Pelvic TB


[edit] Emergency Contraception Options

  • EE and progestin
    • Up to 72 hrs postcoital (3 days)
  • Levonorgestrel
    • Up to 72 hrs postcoital (3 days)
    • Includes Plan B; purchased over the counter
  • Ulipristal acetate (Ella)
    • Up to 120 hrs postcoital (5 days)
    • Requires Rx
  • IUD
    • Up to 120 hrs postcoital (5 days)
    • Requires visit to MD.


  • Indications:
    • Intercourse within past 72-120 hours without contraceptive protection (independent of time in the menstrual cycle)
    • Contraceptive mishap
    • Barrier method dislodgment/breakage
    • Expulsion of IUD
    • Missed oral contraceptive pills
    • Sexual assault
    • Exposure to teratogens (eg, cytotoxic drug)
      • Retinae


  • Hormonal emergency contraception:
    • Not new concept
    • 1920’s: Veterinarians used high doses of estrogen for dogs and horses
    • 1960’s: DES and other estrogens prescribed for human postcoital use
    • 1972  : “Yuzpe method”
      • 100 mcg ethinyl estradiol (high dose birth control pill)
      • 0.5 mg levonorgestrel


  • Yuzpe method:
    • No better and maybe less effective than just using progestin alone.
    • High side effects (n/v)
    • Requries prescription.


[edit] Permanent Birth Control

  • Vasectomy
    • Office procedure
    • Ligation
  • Tubal ligation
    • In-hospital
    • Laproscopic or post-deliver with umbilical incision
  • Hysteroscopic Tubal Sterilization
    • Radiofrequency or silicon plug
    • Can be done in the office
    • Decreasing the cost of tubal ligation.
    • Requires follow-up via radiology.

[edit] Elective Abortions

  • Decrease in number and rate.
  • Decrease in abortion-related deaths.
  • Maternal mortality is actually increasing though (independent of abortions).
  • 950% are done in the first trimester


  • Two major methods:
    • Surgical: D&C
    • Medication
      • 15% of abortions
      • RU486 = Mithacristone (600mg)
      • Can use lower doses but give more vaginally (for fewer side effects)
      • Methotrexate can also be used, but worse

[edit] Questions

  • Slowest return to fertility:
    • Depot medroxyprogesterone acetate


  • Contraindications to CHC (combined hormone contraceptive):
    • DVT!
    • Not the smoker (until over 35yo), not the rheumatoid arthritic, not the well-controlled HTN (OK while controlled)


  • Contraindication to IUD:
    • ?
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