Herpes simplex encephalitis

From Psy3242

Summary

Herpes Simplex Encephalitis (HSE) is caused by Herpes simplex virus type 1 (HSV-1). HSV-1 induces programmed cell death in neuronal cells but it is not clear if the HSE is triggered by the virus itself or the immune system�s response to the infection. In any case, HSE attacks the brain causing bilateral focal damage that is usually localized to the medial temporal lobes, through sometimes spreading to the inferior temporal and frontal temporal areas also. HSE results in severe memory deficits and occasionally executive deficits as well. Because of the bilateral destruction of the medial temporal lobe global amnesia can be suffered by survivors.

Clive Wearing

Clive was a famous case study, who became left globally amnesic as a result of HSE. His hippocampus was damaged as well as his medial and temporal and frontal lobes, likewise the amygdala was also damged. As a result of theese injuries Clive was unable to convert working memories into episodic memories. However,his task related memories remained intact, including his musical ability. His love for his wife was also remembered. He often reported that any given moment was the first time he was awake. Below is a picture of his Journal and the link to video we wached in class.