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The maximum drawdown of trading system is understood to be the best peak-to-valley drawdown in a trading methods value. Lets say like that we have a system that reaches a particular value peak of $100,000. Lets further say that two weeks later, the trading system equ...
 
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No discussion of trading system analysis would be complete without a discussion of drawdown. We must always consider the utmost drawdown of any trading system since it is very, very essential.
+
Home Genes Phenotypes Expression Recombinases Function Pathways Strains / SNPs Orthology Tumors
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  About  Help  FAQ
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The most drawdown of trading system means the greatest peak-to-valley drawdown in a trading methods money. Allows say for example that we've a system that reaches a certain money top of $100,000. Allows further say that two weeks later, the trading process money is at $80,000. In this example, lets say that the $80,000 equity is actually an equity valley. If so, the peak-to-valley drawdown would be $100,000-$80,000 means $20,000. Which means that the maximum drawdown is $20,000.
 
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So just why could be the maximum drawdown this important dimension in our examination of a trading system? Its since the maximum drawdown gives us a measure of the survivability of the trading system. An easy measure, but a measure nevertheless. Fundamentally, when we look at the maximum drawdown we can say this maximum drawdown can happen again at any moment through the entire life of the trading system. This is especially important in regards to analyzing beginning account size.  
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Manln16LG/J
 +
QTL Variant Detail
 +
Nomenclature | Variant origin | Variant description | Phenotypes | Notes | References
 +
Nomenclature
 +
QTL variant: Manln16LG/J
 +
Name: mandible length 16; LG/J
 +
MGI ID: MGI:3528368
 +
QTL: Manln16  Location: unknown    Genetic Position: Chr14, cM position of peak correlated region/allele: 11.53 cM
 +
Variant
 +
origin
 +
Strain of Specimen: LG/J
 +
Variant
 +
description
 +
Allele Type: QTL
 +
Mutation: Undefined
 +
  This allele confers increased mandible length compared to SM/J. (J:93171)
 +
Inheritance: Other (see notes)
 +
Phenotypes
 +
Key:
 +
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
 +
cn conditional genotype cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
 +
Genotypes:
 +
Genotype
 +
Allelic Composition
 +
Genetic Background
 +
Cell Line(s)
 +
hm1
 +
Manln16LG/J/Manln16LG/J
 +
involves: LG/J * SM/J
 +
 +
ht2
 +
Manln16LG/J/Manln16SM/J
 +
involves: LG/J * SM/J
 +
 +
Phenotypes:
 +
Affected Systems
 +
hm1
 +
ht2
 +
show or hide all annotated terms
 +
 +
craniofacial
 +
√ √
 +
skeleton
 +
√ √
 +
View phenotypes for all genotypes (concatenated display).
 +
Notes Manln16 exhibit additive inheritance.
 +
Mapping and Phenotype information for this QTL, its variants and associated markers
-
For instance, lets say that you began to trade the machine utilizing an account financed with $10,000. Next to the bat, you can see that this would not be prudent, since if we went in to a drawdown immediately after starting our account as we can see from our maximum drawdown number our account balance would logically be damaged.  
+
(J:93171)
 +
Two different intercrosses totaling 1045 (LG/J x SM/J)F2 intercross animals were used for linkage analysis to identify QTLs for mandible length. A total of 96 microsatellite markers at an average spacing of 23 cM were used in the genome scan. The QTLs identified for mandible length were evaluated for relationship to other mandible traits. 13 QTLs reaching the chromosome- and genome-wide significance threshold of 0.05 were identified.
-
We is able to see from this quick example that we definitely have to fund our account with more money than enough to cover the utmost trading process drawdown. It makes sense to have a load of some kind as well.  
+
Manln1 (mandible length 1) mapped to 48 cM on mouse Chromosome 1 near D1Mit7 (LOD=8.66). The QTL interval of Manln1 spans 36 cM - 52 cM. LG/J-derived alleles confer increased mandible length at Manln1 with a dominant mode of inheritance. This locus explains 4% of the variance.
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I'd exercise caution, if you should be looking a system and the recommended account size is maximum drawdown as the exact same size.  
+
Manln2 mapped to 52 cM on mouse Chromosome 2 near D2Mit370 (LOD=4.64). The QTL interval of Manln2 spans 42 cM - 60 cM. This locus is linked to many different mandible traits affecting the muscle attachment area.
-
The most drawdown is definitely an necessary measure that offers a better idea to us of what to expect when trading a particular system. A comparison of risk versus reward is definitely an absolute essential in successful trading.  
+
Manln3 mapped to 34 cM on mouse Chromosome 3 in linkage to D3Mit22 (LOD=2.75). The QTL interval of Manln3 spans 14 cM - 56 cM. LG/J-derived alleles confer increased mandible length at Manln3 with a dominant mode of inheritance. This locus explains 1.3% of the variance. Manln3 also shows linkage to several different mandible traits affectingthe alveolar processes (LOD=7.75 at D3Mit22).
-
To Your Forex Currency Trading Success! The most drawdown of trading system means the greatest peak-to-valley drawdown in a trading programs value. Lets say like that we've a system that reaches a particular equity peak of $100,000. Lets further say that fourteen days later, the trading process equ...  
+
Manln4 mapped to 16 cM on mouse Chromosome 4 near D4Mit163 (LOD=3.46). The QTL interval of Manln4 spans 8 cM - 20 cM. This locus is linked to several different mandible traits affecting muscle attachment region. Manln5 mapped to 36 cM near D4Mit17 (LOD=4.94). The QTL interval of Manln5 spans 24 cM - 52 cM. LG/J-derived alleles at Manln5 confer increased mandible length with a dominant mode of inheritance. This locus explains 2.3% of the variance.
-
No discussion of trading system analysis will be complete without a discussion of drawdown. We must always go through the maximum drawdown of any trading system since it is very, very important.  
+
Manln6 mapped to 92 cM on mouse Chromosome 6 near D6Mit58 (LOD=3.13). The QTL interval of Manln6 spans 92 cM - 96 cM. LG/J-derived alleles at Manln6 confer increased mandible length with a recessive mode of inheritance. This locus explains 1.5% of the variance.
-
the best peak-to-valley drawdown in a trading programs value the utmost drawdown of trading system is defined. Allows say as an example that we have a system that reaches a particular money peak of $100,000. Lets further say that fourteen days later, the trading system equity are at $80,000. In this instance, lets say that the $80,000 equity happens to be an equity pit. If that's the case, the peak-to-valley drawdown could be $100,000-$80,000 equals $20,000. This means that the maximum drawdown is $20,000.  
+
Manln7 mapped to 18 cM on mouse Chromosome 7 near D7Mit21 (LOD=3.43). The QTL interval of Manln7 spans 0 cM - 32 cM. Manln7 shows linkage to superior condyloid length. Manln8 mapped to 50 cM near D7Nds1 (LOD=4.14). The QTL interval of Manln8 spans 40 cM - 56 cM. LG/J-derived alleles at Manln8 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.9% of the variance.
-
So just why may be the maximum drawdown this important dimension inside our examination of a trading system? Its because the maximum drawdown gives a measure to us of the survivability of the trading system. An easy measure, but a measure nonetheless. Basically, when we look at the maximum drawdown we can say that maximum drawdown can happen again at any time through the life of the trading system. As it pertains to assessing beginning bill size this really is especially important.  
+
Manln9 mapped to 88 cM on mouse Chromosome 10 near D10Mit133 (LOD=4.24). The QTL interval of Manln9 spans 62 cM - 88 cM. LG/J-derived alleles at Manln9 confer increased mandible length with a dominant mode of inheritance. This locus explains 2% of the variance.
-
As an example, lets say that you started to trade the machine utilizing an account financed with $10,000. Right off the bat, you can see that this wouldn't be sensible, since if we went in to a drawdown immediately after starting our account as we can see from our maximum drawdown number our account balance would practically be damaged.  
+
Manln10 mapped to 0 cM on mouse Chromosome 11 near D11Mit62 (LOD=2.64). The QTL interval of Manln10 spans 0 cM - 56 cM. Manln10 is linked to several mandible traits affecting the muscle attachment region. Manln11 mapped to 50 cM on mouse Chromosome 11 near D11Mit64 (LOD=11.88). The QTL interval of Manln11 spans 30 cM - 72 cM. LG/J-derived alleles atManln11 confer increased mandible length with a dominant mode of inheritance. This locus explains 5.5% of the variance. Manln12 mapped to 98 cM near D11Mit333 (LOD=3.53). This locus is linked to several different mandible traits affecting the muscle attachment region and alveolar processes.
-
We can easily see out of this quick representation that we certainly need to fund our account with increased money than enough to cover the maximum trading system drawdown. Perfect sense is made by it to truly have a stream of some type as well.  
+
Manln13 mapped to 24 cM on mouse Chromosome 13 near D13Mit115 (LOD=3.42). The QTL interval of Manln13 spans 8 cM - 44 cM. LG/J-derived alleles at Manln13 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.6% of the variance. Manln14 mapped to 74 cM near D13Mit9 (LOD=3.68). The QTL interval of Manln14 spans 54 cM - 92 cM. LG/J-derived alleles at Manln14 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.7% of the variance.
-
I would exercise caution, if you are looking a system and the recommended bill size is the identical size while the maximum drawdown.  
+
Manln15 mapped to 0 cM on mouse Chromosome 14 near D14Nds1 (LOD=2.52). The QTL interval of Manln15 spans 0 cM - 14 cM. This locus is linked to several different mandible traits affecting the muscle attachment regionand alveolar processes. Manln16 mapped to 16 cM near D14Nds1 (LOD=7.25). The QTL interval of Manln16 spans 4 cM - 28 cM. LG/J-derived alleles at Manln16 confer increased mandible length with an additive mode of inheritance. This locus explains 3.4% of the variance.
-
The most drawdown is definitely an essential measure that provides us a better idea of what things to expect when investing a certain program. A comparison of risk versus reward can be an absolute essential in successful trading.  
+
Manln17 mapped to 38 cM on mouse Chromosome 15 near D15Mit5 (LOD=7.59). The QTL interval of Manln17 spans 28 cM - 46 cM. LG/J-derived alleles at Manln17 confer increased mandible length with a dominant mode of inheritance. This locus explains 3.5% of the variance.
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To Your Currency Trading Success!
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Manln18 mapped to 8 cM on mouse Chromosome 17 near D17Mit46 (LOD=4.76). The QTL interval of Manln18 spans 0 cM - 18 cM. LG/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains2.4% of the variance.
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== la sobriété de son style ==
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Manln19 mapped to 0 cM on mouse Chromosome 19 near D19Mit16 (LOD=2.46). The QTL interval of Manln19 spans 0 cM - 40 cM. SM/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains 1.1% of the variance.
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Ce meuble chinois est réalisé artisanalement, peint et décoré à la main. De ce fait,franklin marshall pas cher, chaque laque, dessin ou disposition des motifs est unique et peut varier légèrement d meuble à un autre. Les arbres utilisés proviennent de plantations éco-certifiées. <br><br>Certains sont alors devenus des personnes qui ont complètement oublié la dimension de lumière. D'autres encore ont plutôt préféré favoriser leur ego et servir la lumière en fonction de celui-ci. Donc,hollister soldes, pour beaucoup, la structure en question est partielle voire inexistante. <br><br>«George Balanchine (chorégraphe russe passé par Paris avant de créer le New York City Ballet) aimait beaucoup travailler avec l'Opéra de Paris. Il appréciait la richesse de son école, la sobriété de son style,franklin marshall france, la pérennité de sa tradition, et les infinies possibilités qu'elle offrait pour un chorégraphe. Noureev s'inscrivit à mon sens dans la même perspective,chaussures adidas.» Ici ou là,adidas pas cher, les danseurs de renom n'ont pas toujours cette «élégance»: on voit des solistes russes ou cubains explosifs et virtuoses mais dénués parfois d'intériorité.. <br><br>La rencontre qui s'est déroulée à la Faculté de l'aménagement a donné l'occasion à trois professeurs de l'Université de Montréal de faire connaitre leurs points de vue sur «le campus de l'avenir». Pour Jean-Marie Van der Maren,adidas homme, professeur à la Faculté des sciences de l'éducation, il faut faire son choix entre l'université «classique» ou «scientifique». La première,hollister, qui a essaimé partout en Occident entre les 15e et 20e siècles, est faite de bâtiments disséminés dans la ville.
 
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Related articles:
 
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<ul>
 
-
 
 
-
  <li>Au cours des dernières années</li>
 
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  <li>est-ce que tu peux enlever ces lunettes pour que je puisse voir tes yeux</li>
 
-
 
 
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  <li>vient de remporter MAGNUM</li>
 
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</ul>
 
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== ou inversement ==
+
References
 +
Original: J:93171 Cheverud JM et al., "Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration." J Exp Zoolog Part A Comp Exp Biol 2004 Sep 21;302B(5):424-35
 +
All: 1 reference(s)
 +
Contributing Projects:
 +
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
 +
Citing These Resources
 +
Funding Information
 +
Warranty Disclaimer & Copyright Notice
 +
Send questions and comments to User Support. last database update
 +
04/03/2013
 +
MGI 5.12  
 +
Home Genes Phenotypes Expression Recombinases Function Pathways Strains / SNPs Orthology Tumors
 +
 +
  About  Help  FAQ
 +
 +
Search
 +
Download
 +
More Resources
 +
Submit Data
 +
Find Mice (IMSR)
 +
Analysis Tools
 +
Contact Us
-
2013 est l'année de l'épreuve et de la lumière. Vous pouvez très bien vous transformer à tel point que vous ne pourriez plus vous reconnaître (dans la lumière,adidas femme, ou inversement). La vérité va être révélée, et il était temps. Aujourd'hui,franklin marshall, en voyant le calendrier, je me suis rendu compte que le compte à rebours est réellement commencé. En ce 11 décembre, il ne me reste plus qu'un mois jour pour jour en Amérique latine. Même si,chaussures adidas homme, le mois dernier, j'écrivais que je m'ennuyais de Montréal (ce qui est toujours vrai), je sais que ça ne sera sûrement pas si facile partir pour l'aéroport et dire au revoir au Chili et à certains amis que je me suis fait ici,hollister soldes. <br><br>Maintenir la chaîne du froid pour les vaccins coûte en effet des millions de dollars chaque année. En 2000,hollister pas cher, les dépenses de vaccination dans les pays à faibles revenus représentaient une moyenne de 6 dollars É.-U. par naissance vivante pour l En 2010, le coût de vaccination avec les vaccins traditionnels et ceux contre l B et les infections à haemophilus influenzae de type b (Hib)3 a atteint selon l 18 dollars É,franklin marshall soldes.-U. <br><br>Il est intéressant de noter que, parmi les rubriques proposées,adidas pas cher, c'est celle des Emplois fautifs qui fut la plus consultée, suivie à égalité par Extensions de sens, Bonheurs et surprises et Néologismes et anglicismes. Les bloc-notes sont régulièrement lus. C'est donc, en moyenne, 4500 internautes qui s'informent chaque mois des propositions de notre site Dire, Ne pas dire. <br><br>Dans le cadre de la semaine nationale du football au F閙inin, la Vitr閑enne FC en accord avec la FFF et la ligue de Bretagne de Football accueillera la rencontre de haut niveau f閙inin : En Avant Guingamp vs QKFC Quimper, avec la pr閟ence exceptionnelle de Camille ABILY, attaquante de l'閝uipe de France et marraine de la VITREENNE FC (100 % filles . 100 % fun . 100 % foot ).
+
 
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Related articles:
+
Manln16LG/J
-
<ul>
+
QTL Variant Detail
-
 
+
Nomenclature | Variant origin | Variant description | Phenotypes | Notes | References
-
  <li>occidentale.</li>
+
Nomenclature
-
 
+
QTL variant: Manln16LG/J
-
  <li>The Faculty of Law</li>
+
Name: mandible length 16; LG/J
-
 
+
MGI ID: MGI:3528368
-
  <li>qui dure plus de six minutes</li>
+
QTL: Manln16  Location: unknown    Genetic Position: Chr14, cM position of peak correlated region/allele: 11.53 cM
-
 
+
Variant
-
  </ul>
+
origin
 +
Strain of Specimen: LG/J
 +
Variant
 +
description
 +
Allele Type: QTL
 +
Mutation: Undefined
 +
  This allele confers increased mandible length compared to SM/J. (J:93171)
 +
Inheritance: Other (see notes)
 +
Phenotypes
 +
Key:
 +
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
 +
cn conditional genotype cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
 +
Genotypes:
 +
Genotype
 +
Allelic Composition
 +
Genetic Background
 +
Cell Line(s)
 +
hm1
 +
Manln16LG/J/Manln16LG/J
 +
involves: LG/J * SM/J
 +
 +
ht2
 +
Manln16LG/J/Manln16SM/J
 +
involves: LG/J * SM/J
 +
 +
Phenotypes:
 +
Affected Systems
 +
hm1
 +
ht2
 +
show or hide all annotated terms
 +
 +
craniofacial
 +
√ √
 +
skeleton
 +
√ √
 +
View phenotypes for all genotypes (concatenated display).
 +
Notes Manln16 exhibit additive inheritance.
 +
Mapping and Phenotype information for this QTL, its variants and associated markers
 +
 
 +
(J:93171)
 +
Two different intercrosses totaling 1045 (LG/J x SM/J)F2 intercross animals were used for linkage analysis to identify QTLs for mandible length. A total of 96 microsatellite markers at an average spacing of 23 cM were used in the genome scan. The QTLs identified for mandible length were evaluated for relationship to other mandible traits. 13 QTLs reaching the chromosome- and genome-wide significance threshold of 0.05 were identified.
 +
 
 +
Manln1 (mandible length 1) mapped to 48 cM on mouse Chromosome 1 near D1Mit7 (LOD=8.66). The QTL interval of Manln1 spans 36 cM - 52 cM. LG/J-derived alleles confer increased mandible length at Manln1 with a dominant mode of inheritance. This locus explains 4% of the variance.
 +
 
 +
Manln2 mapped to 52 cM on mouse Chromosome 2 near D2Mit370 (LOD=4.64). The QTL interval of Manln2 spans 42 cM - 60 cM. This locus is linked to many different mandible traits affecting the muscle attachment area.
 +
 
 +
Manln3 mapped to 34 cM on mouse Chromosome 3 in linkage to D3Mit22 (LOD=2.75). The QTL interval of Manln3 spans 14 cM - 56 cM. LG/J-derived alleles confer increased mandible length at Manln3 with a dominant mode of inheritance. This locus explains 1.3% of the variance. Manln3 also shows linkage to several different mandible traits affectingthe alveolar processes (LOD=7.75 at D3Mit22).
 +
 
 +
Manln4 mapped to 16 cM on mouse Chromosome 4 near D4Mit163 (LOD=3.46). The QTL interval of Manln4 spans 8 cM - 20 cM. This locus is linked to several different mandible traits affecting muscle attachment region. Manln5 mapped to 36 cM near D4Mit17 (LOD=4.94). The QTL interval of Manln5 spans 24 cM - 52 cM. LG/J-derived alleles at Manln5 confer increased mandible length with a dominant mode of inheritance. This locus explains 2.3% of the variance.
 +
 
 +
Manln6 mapped to 92 cM on mouse Chromosome 6 near D6Mit58 (LOD=3.13). The QTL interval of Manln6 spans 92 cM - 96 cM. LG/J-derived alleles at Manln6 confer increased mandible length with a recessive mode of inheritance. This locus explains 1.5% of the variance.
 +
 
 +
Manln7 mapped to 18 cM on mouse Chromosome 7 near D7Mit21 (LOD=3.43). The QTL interval of Manln7 spans 0 cM - 32 cM. Manln7 shows linkage to superior condyloid length. Manln8 mapped to 50 cM near D7Nds1 (LOD=4.14). The QTL interval of Manln8 spans 40 cM - 56 cM. LG/J-derived alleles at Manln8 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.9% of the variance.
 +
 
 +
Manln9 mapped to 88 cM on mouse Chromosome 10 near D10Mit133 (LOD=4.24). The QTL interval of Manln9 spans 62 cM - 88 cM. LG/J-derived alleles at Manln9 confer increased mandible length with a dominant mode of inheritance. This locus explains 2% of the variance.
 +
 
 +
Manln10 mapped to 0 cM on mouse Chromosome 11 near D11Mit62 (LOD=2.64). The QTL interval of Manln10 spans 0 cM - 56 cM. Manln10 is linked to several mandible traits affecting the muscle attachment region. Manln11 mapped to 50 cM on mouse Chromosome 11 near D11Mit64 (LOD=11.88). The QTL interval of Manln11 spans 30 cM - 72 cM. LG/J-derived alleles atManln11 confer increased mandible length with a dominant mode of inheritance. This locus explains 5.5% of the variance. Manln12 mapped to 98 cM near D11Mit333 (LOD=3.53). This locus is linked to several different mandible traits affecting the muscle attachment region and alveolar processes.
 +
 
 +
Manln13 mapped to 24 cM on mouse Chromosome 13 near D13Mit115 (LOD=3.42). The QTL interval of Manln13 spans 8 cM - 44 cM. LG/J-derived alleles at Manln13 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.6% of the variance. Manln14 mapped to 74 cM near D13Mit9 (LOD=3.68). The QTL interval of Manln14 spans 54 cM - 92 cM. LG/J-derived alleles at Manln14 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.7% of the variance.
 +
 
 +
Manln15 mapped to 0 cM on mouse Chromosome 14 near D14Nds1 (LOD=2.52). The QTL interval of Manln15 spans 0 cM - 14 cM. This locus is linked to several different mandible traits affecting the muscle attachment regionand alveolar processes. Manln16 mapped to 16 cM near D14Nds1 (LOD=7.25). The QTL interval of Manln16 spans 4 cM - 28 cM. LG/J-derived alleles at Manln16 confer increased mandible length with an additive mode of inheritance. This locus explains 3.4% of the variance.
 +
 
 +
Manln17 mapped to 38 cM on mouse Chromosome 15 near D15Mit5 (LOD=7.59). The QTL interval of Manln17 spans 28 cM - 46 cM. LG/J-derived alleles at Manln17 confer increased mandible length with a dominant mode of inheritance. This locus explains 3.5% of the variance.
 +
 
 +
Manln18 mapped to 8 cM on mouse Chromosome 17 near D17Mit46 (LOD=4.76). The QTL interval of Manln18 spans 0 cM - 18 cM. LG/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains2.4% of the variance.
 +
 
 +
Manln19 mapped to 0 cM on mouse Chromosome 19 near D19Mit16 (LOD=2.46). The QTL interval of Manln19 spans 0 cM - 40 cM. SM/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains 1.1% of the variance.
 +
 
 +
 
 +
References
 +
Original: J:93171 Cheverud JM et al., "Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration." J Exp Zoolog Part A Comp Exp Biol 2004 Sep 21;302B(5):424-35
 +
All: 1 reference(s)
 +
Contributing Projects:
 +
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
 +
Citing These Resources
 +
Funding Information
 +
Warranty Disclaimer & Copyright Notice
 +
Send questions and comments to User Support. last database update
 +
04/03/2013
 +
MGI 5.12

Revision as of 03:29, 12 April 2013

Home Genes Phenotypes Expression Recombinases Function Pathways Strains / SNPs Orthology Tumors 

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Manln16LG/J QTL Variant Detail Nomenclature | Variant origin | Variant description | Phenotypes | Notes | References Nomenclature QTL variant: Manln16LG/J Name: mandible length 16; LG/J MGI ID: MGI:3528368 QTL: Manln16 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 11.53 cM Variant origin Strain of Specimen: LG/J Variant description Allele Type: QTL Mutation: Undefined 

	  	This allele confers increased mandible length compared to SM/J. (J:93171)

Inheritance: Other (see notes) Phenotypes Key: hm homozygous ht heterozygous tg involves transgenes √ phenotype observed cn conditional genotype cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype Genotypes: Genotype Allelic Composition Genetic Background Cell Line(s) hm1 Manln16LG/J/Manln16LG/J involves: LG/J * SM/J

ht2 Manln16LG/J/Manln16SM/J involves: LG/J * SM/J

Phenotypes: Affected Systems hm1 ht2 show or hide all annotated terms

craniofacial √ √ skeleton √ √ View phenotypes for all genotypes (concatenated display). Notes Manln16 exhibit additive inheritance. Mapping and Phenotype information for this QTL, its variants and associated markers

(J:93171) Two different intercrosses totaling 1045 (LG/J x SM/J)F2 intercross animals were used for linkage analysis to identify QTLs for mandible length. A total of 96 microsatellite markers at an average spacing of 23 cM were used in the genome scan. The QTLs identified for mandible length were evaluated for relationship to other mandible traits. 13 QTLs reaching the chromosome- and genome-wide significance threshold of 0.05 were identified.

Manln1 (mandible length 1) mapped to 48 cM on mouse Chromosome 1 near D1Mit7 (LOD=8.66). The QTL interval of Manln1 spans 36 cM - 52 cM. LG/J-derived alleles confer increased mandible length at Manln1 with a dominant mode of inheritance. This locus explains 4% of the variance.

Manln2 mapped to 52 cM on mouse Chromosome 2 near D2Mit370 (LOD=4.64). The QTL interval of Manln2 spans 42 cM - 60 cM. This locus is linked to many different mandible traits affecting the muscle attachment area.

Manln3 mapped to 34 cM on mouse Chromosome 3 in linkage to D3Mit22 (LOD=2.75). The QTL interval of Manln3 spans 14 cM - 56 cM. LG/J-derived alleles confer increased mandible length at Manln3 with a dominant mode of inheritance. This locus explains 1.3% of the variance. Manln3 also shows linkage to several different mandible traits affectingthe alveolar processes (LOD=7.75 at D3Mit22).

Manln4 mapped to 16 cM on mouse Chromosome 4 near D4Mit163 (LOD=3.46). The QTL interval of Manln4 spans 8 cM - 20 cM. This locus is linked to several different mandible traits affecting muscle attachment region. Manln5 mapped to 36 cM near D4Mit17 (LOD=4.94). The QTL interval of Manln5 spans 24 cM - 52 cM. LG/J-derived alleles at Manln5 confer increased mandible length with a dominant mode of inheritance. This locus explains 2.3% of the variance.

Manln6 mapped to 92 cM on mouse Chromosome 6 near D6Mit58 (LOD=3.13). The QTL interval of Manln6 spans 92 cM - 96 cM. LG/J-derived alleles at Manln6 confer increased mandible length with a recessive mode of inheritance. This locus explains 1.5% of the variance.

Manln7 mapped to 18 cM on mouse Chromosome 7 near D7Mit21 (LOD=3.43). The QTL interval of Manln7 spans 0 cM - 32 cM. Manln7 shows linkage to superior condyloid length. Manln8 mapped to 50 cM near D7Nds1 (LOD=4.14). The QTL interval of Manln8 spans 40 cM - 56 cM. LG/J-derived alleles at Manln8 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.9% of the variance.

Manln9 mapped to 88 cM on mouse Chromosome 10 near D10Mit133 (LOD=4.24). The QTL interval of Manln9 spans 62 cM - 88 cM. LG/J-derived alleles at Manln9 confer increased mandible length with a dominant mode of inheritance. This locus explains 2% of the variance.

Manln10 mapped to 0 cM on mouse Chromosome 11 near D11Mit62 (LOD=2.64). The QTL interval of Manln10 spans 0 cM - 56 cM. Manln10 is linked to several mandible traits affecting the muscle attachment region. Manln11 mapped to 50 cM on mouse Chromosome 11 near D11Mit64 (LOD=11.88). The QTL interval of Manln11 spans 30 cM - 72 cM. LG/J-derived alleles atManln11 confer increased mandible length with a dominant mode of inheritance. This locus explains 5.5% of the variance. Manln12 mapped to 98 cM near D11Mit333 (LOD=3.53). This locus is linked to several different mandible traits affecting the muscle attachment region and alveolar processes.

Manln13 mapped to 24 cM on mouse Chromosome 13 near D13Mit115 (LOD=3.42). The QTL interval of Manln13 spans 8 cM - 44 cM. LG/J-derived alleles at Manln13 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.6% of the variance. Manln14 mapped to 74 cM near D13Mit9 (LOD=3.68). The QTL interval of Manln14 spans 54 cM - 92 cM. LG/J-derived alleles at Manln14 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.7% of the variance.

Manln15 mapped to 0 cM on mouse Chromosome 14 near D14Nds1 (LOD=2.52). The QTL interval of Manln15 spans 0 cM - 14 cM. This locus is linked to several different mandible traits affecting the muscle attachment regionand alveolar processes. Manln16 mapped to 16 cM near D14Nds1 (LOD=7.25). The QTL interval of Manln16 spans 4 cM - 28 cM. LG/J-derived alleles at Manln16 confer increased mandible length with an additive mode of inheritance. This locus explains 3.4% of the variance.

Manln17 mapped to 38 cM on mouse Chromosome 15 near D15Mit5 (LOD=7.59). The QTL interval of Manln17 spans 28 cM - 46 cM. LG/J-derived alleles at Manln17 confer increased mandible length with a dominant mode of inheritance. This locus explains 3.5% of the variance.

Manln18 mapped to 8 cM on mouse Chromosome 17 near D17Mit46 (LOD=4.76). The QTL interval of Manln18 spans 0 cM - 18 cM. LG/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains2.4% of the variance.

Manln19 mapped to 0 cM on mouse Chromosome 19 near D19Mit16 (LOD=2.46). The QTL interval of Manln19 spans 0 cM - 40 cM. SM/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains 1.1% of the variance.


References Original: J:93171 Cheverud JM et al., "Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration." J Exp Zoolog Part A Comp Exp Biol 2004 Sep 21;302B(5):424-35 All: 1 reference(s) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. last database update 04/03/2013 MGI 5.12 Home Genes Phenotypes Expression Recombinases Function Pathways Strains / SNPs Orthology Tumors 

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Manln16LG/J QTL Variant Detail Nomenclature | Variant origin | Variant description | Phenotypes | Notes | References Nomenclature QTL variant: Manln16LG/J Name: mandible length 16; LG/J MGI ID: MGI:3528368 QTL: Manln16 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 11.53 cM Variant origin Strain of Specimen: LG/J Variant description Allele Type: QTL Mutation: Undefined 

	  	This allele confers increased mandible length compared to SM/J. (J:93171)

Inheritance: Other (see notes) Phenotypes Key: hm homozygous ht heterozygous tg involves transgenes √ phenotype observed cn conditional genotype cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype Genotypes: Genotype Allelic Composition Genetic Background Cell Line(s) hm1 Manln16LG/J/Manln16LG/J involves: LG/J * SM/J

ht2 Manln16LG/J/Manln16SM/J involves: LG/J * SM/J

Phenotypes: Affected Systems hm1 ht2 show or hide all annotated terms

craniofacial √ √ skeleton √ √ View phenotypes for all genotypes (concatenated display). Notes Manln16 exhibit additive inheritance. Mapping and Phenotype information for this QTL, its variants and associated markers

(J:93171) Two different intercrosses totaling 1045 (LG/J x SM/J)F2 intercross animals were used for linkage analysis to identify QTLs for mandible length. A total of 96 microsatellite markers at an average spacing of 23 cM were used in the genome scan. The QTLs identified for mandible length were evaluated for relationship to other mandible traits. 13 QTLs reaching the chromosome- and genome-wide significance threshold of 0.05 were identified.

Manln1 (mandible length 1) mapped to 48 cM on mouse Chromosome 1 near D1Mit7 (LOD=8.66). The QTL interval of Manln1 spans 36 cM - 52 cM. LG/J-derived alleles confer increased mandible length at Manln1 with a dominant mode of inheritance. This locus explains 4% of the variance.

Manln2 mapped to 52 cM on mouse Chromosome 2 near D2Mit370 (LOD=4.64). The QTL interval of Manln2 spans 42 cM - 60 cM. This locus is linked to many different mandible traits affecting the muscle attachment area.

Manln3 mapped to 34 cM on mouse Chromosome 3 in linkage to D3Mit22 (LOD=2.75). The QTL interval of Manln3 spans 14 cM - 56 cM. LG/J-derived alleles confer increased mandible length at Manln3 with a dominant mode of inheritance. This locus explains 1.3% of the variance. Manln3 also shows linkage to several different mandible traits affectingthe alveolar processes (LOD=7.75 at D3Mit22).

Manln4 mapped to 16 cM on mouse Chromosome 4 near D4Mit163 (LOD=3.46). The QTL interval of Manln4 spans 8 cM - 20 cM. This locus is linked to several different mandible traits affecting muscle attachment region. Manln5 mapped to 36 cM near D4Mit17 (LOD=4.94). The QTL interval of Manln5 spans 24 cM - 52 cM. LG/J-derived alleles at Manln5 confer increased mandible length with a dominant mode of inheritance. This locus explains 2.3% of the variance.

Manln6 mapped to 92 cM on mouse Chromosome 6 near D6Mit58 (LOD=3.13). The QTL interval of Manln6 spans 92 cM - 96 cM. LG/J-derived alleles at Manln6 confer increased mandible length with a recessive mode of inheritance. This locus explains 1.5% of the variance.

Manln7 mapped to 18 cM on mouse Chromosome 7 near D7Mit21 (LOD=3.43). The QTL interval of Manln7 spans 0 cM - 32 cM. Manln7 shows linkage to superior condyloid length. Manln8 mapped to 50 cM near D7Nds1 (LOD=4.14). The QTL interval of Manln8 spans 40 cM - 56 cM. LG/J-derived alleles at Manln8 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.9% of the variance.

Manln9 mapped to 88 cM on mouse Chromosome 10 near D10Mit133 (LOD=4.24). The QTL interval of Manln9 spans 62 cM - 88 cM. LG/J-derived alleles at Manln9 confer increased mandible length with a dominant mode of inheritance. This locus explains 2% of the variance.

Manln10 mapped to 0 cM on mouse Chromosome 11 near D11Mit62 (LOD=2.64). The QTL interval of Manln10 spans 0 cM - 56 cM. Manln10 is linked to several mandible traits affecting the muscle attachment region. Manln11 mapped to 50 cM on mouse Chromosome 11 near D11Mit64 (LOD=11.88). The QTL interval of Manln11 spans 30 cM - 72 cM. LG/J-derived alleles atManln11 confer increased mandible length with a dominant mode of inheritance. This locus explains 5.5% of the variance. Manln12 mapped to 98 cM near D11Mit333 (LOD=3.53). This locus is linked to several different mandible traits affecting the muscle attachment region and alveolar processes.

Manln13 mapped to 24 cM on mouse Chromosome 13 near D13Mit115 (LOD=3.42). The QTL interval of Manln13 spans 8 cM - 44 cM. LG/J-derived alleles at Manln13 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.6% of the variance. Manln14 mapped to 74 cM near D13Mit9 (LOD=3.68). The QTL interval of Manln14 spans 54 cM - 92 cM. LG/J-derived alleles at Manln14 confer increased mandible length with a dominant mode of inheritance. This locus explains 1.7% of the variance.

Manln15 mapped to 0 cM on mouse Chromosome 14 near D14Nds1 (LOD=2.52). The QTL interval of Manln15 spans 0 cM - 14 cM. This locus is linked to several different mandible traits affecting the muscle attachment regionand alveolar processes. Manln16 mapped to 16 cM near D14Nds1 (LOD=7.25). The QTL interval of Manln16 spans 4 cM - 28 cM. LG/J-derived alleles at Manln16 confer increased mandible length with an additive mode of inheritance. This locus explains 3.4% of the variance.

Manln17 mapped to 38 cM on mouse Chromosome 15 near D15Mit5 (LOD=7.59). The QTL interval of Manln17 spans 28 cM - 46 cM. LG/J-derived alleles at Manln17 confer increased mandible length with a dominant mode of inheritance. This locus explains 3.5% of the variance.

Manln18 mapped to 8 cM on mouse Chromosome 17 near D17Mit46 (LOD=4.76). The QTL interval of Manln18 spans 0 cM - 18 cM. LG/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains2.4% of the variance.

Manln19 mapped to 0 cM on mouse Chromosome 19 near D19Mit16 (LOD=2.46). The QTL interval of Manln19 spans 0 cM - 40 cM. SM/J-derived alleles confer increased mandible length with a dominant mode of inheritance. This locus explains 1.1% of the variance.


References Original: J:93171 Cheverud JM et al., "Pleiotropic effects on mandibular morphology II: Differential epistasis and genetic variation in morphological integration." J Exp Zoolog Part A Comp Exp Biol 2004 Sep 21;302B(5):424-35 All: 1 reference(s) Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support. last database update 04/03/2013 MGI 5.12

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