Adrenal gland
From Iusmphysiology
Revision as of 16:59, 2 March 2011 by 149.166.25.152 (Talk)
- continued here Endocrine control mechanism at 11:11AM on 03/02/11.
Contents |
Adrenal glands
- accidentally baleted notes
Cortex
Glucocorticoids
- An impt stress response
- Glucocorticoids bind with HSPs then homodimerize to go into the nucleus to be a txn factor.
Cortisol effects on various systems
- Acts on many, many tissues.
Mineralocorticoids
- Made by zona glomerulosa
- Aldosterone
- Effects:
- Increases interstitial levels of ...?
- skipped some material
Adrenal diseases
Addison's disease
- JFK had Addison's disease.
- ADrenocortico insufficiency:
- Too little cortisol
- Primary Cause:
- Autoimmune
- Infectious
- Secondary cause
- PIt doesn't make enough ACTH (1 in 100K)
- Presentation:
- Low cortisol,
- hypoglycemia,
- high ACTH
- b/c no feedback, could lead to adrenal hypertrophy,
- could lead to odd coloring
- high sex hormone precursors like ADHEA.
- Adrenal insufficiency occurs in pit in the 2nd and 3rd from the left.
Cushing's syndrome
- Diseases of excess of cortisol
- Could be an adrenal tumor making too much cortisol.
- Causes really low ACTH b/c lots of feedback on the Pit
- An umbrella term for overproduction of ACTH
- If it is a pit ACTH-producing tumor, then it is the disease.
Cushing's disease
- Tumor of the pit htat makes ACTH
- Similar outcome to syndrome (too much cortisol)
- Can tell the diff b/c ACTH is high.
- Presentation:
- Key are high bp and high blood sugar.
Other
- Other tumors that make ACTH or something that mimics ACTH.
Hypoaldosteronism
- He won't test us on enzyme names in the flow chart of steroid production.
- spaced out a bit
Congenital adrenal hyperplasia
- stopped taking notes....
- stopped here on 03/02/11 at 12PM.
