Editing Renal blood flow, glomerular filtration
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**Blood colloid pressure (Pi<sub>GC</sub>) wants to keep stuff in the blood. | **Blood colloid pressure (Pi<sub>GC</sub>) wants to keep stuff in the blood. | ||
***Note that the blood colloid pressure (P<sub>GC</sub>) increases proximal to distal in the capillary as water is filtered out. | ***Note that the blood colloid pressure (P<sub>GC</sub>) increases proximal to distal in the capillary as water is filtered out. | ||
- | **Filtrate colloid pressure (P<sub>FC</sub>) wants to keep stuff in the interstitial fluid | + | **Filtrate colloid pressure (P<sub>FC</sub>) wants to keep stuff in the interstitial fluid. |
**Capillary hydrostatic pressure (P<sub>GC</sub>) wants to force stuff out of the capillary. | **Capillary hydrostatic pressure (P<sub>GC</sub>) wants to force stuff out of the capillary. | ||
- | **Filtrate hydrostatic pressure (P<sub>BS</sub> | + | **Filtrate hydrostatic pressure (P<sub>BS</sub>wants to force fluid into the blood. |
***P<sub>BS</sub> is negligible. | ***P<sub>BS</sub> is negligible. | ||
*There is a constant called the '''glomerular ultrafiltration coefficient (K<sub>f</sub>) that accounts for the normal surface area and capillary permeability. | *There is a constant called the '''glomerular ultrafiltration coefficient (K<sub>f</sub>) that accounts for the normal surface area and capillary permeability. | ||
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*Recall that GFR = K<sub>f</sub> * (P<sub>GC</sub> - P<sub>BS</sub> - Pi<sub>GC</sub>) | *Recall that GFR = K<sub>f</sub> * (P<sub>GC</sub> - P<sub>BS</sub> - Pi<sub>GC</sub>) | ||
*So when Pi<sub>GC</sub> (blood colloid osmotic pressure) decreases, GFR goes up. | *So when Pi<sub>GC</sub> (blood colloid osmotic pressure) decreases, GFR goes up. | ||
- | + | Does giving saline and therefore increasing GFR decrease mean that a higher dose or a more frequent administration of a drug must be given to be effective (because of increased clearance rate)? | |
- | + | ||
===Relationship of glomerular blood flow and GFR=== | ===Relationship of glomerular blood flow and GFR=== |