Editing 20110105 Lecture 4 notes.txt
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===Pain (stimulus noxious to the body)=== | ===Pain (stimulus noxious to the body)=== | ||
*The major information is that sharp pain is transmitted by a-delta fibers (myelinated) and dull / burning pain is by c-fibers (unmyelinated). | *The major information is that sharp pain is transmitted by a-delta fibers (myelinated) and dull / burning pain is by c-fibers (unmyelinated). | ||
- | *Some NT peptides can sensitize for pain (increase the sensitivity) | + | *Some NT peptides can sensitize for pain (increase the sensitivity). |
- | + | ||
*Mechanisms are as follows: | *Mechanisms are as follows: | ||
**P2x mechanism: | **P2x mechanism: | ||
- | ***An ATP | + | ***An ATP dependent mechanism |
***Nail in a hand causes cell damage. | ***Nail in a hand causes cell damage. | ||
***ATP is released | ***ATP is released | ||
- | ***ATP sensitive p2x | + | ***ATP sensitive p2x anatropic channels are on the neurve terminals and are depolarized |
***This causes opening of voltage gated na channels and the propagation of an AP. | ***This causes opening of voltage gated na channels and the propagation of an AP. | ||
- | **ASIC mechanism | + | **ASIC mechanism |
***Proton-sensitive | ***Proton-sensitive | ||
***Organelles release protons | ***Organelles release protons | ||
***Proton sensitive channels cause depolarization and an AP via T2D channels | ***Proton sensitive channels cause depolarization and an AP via T2D channels | ||
- | **K+ release | + | **K+ release |
***Cells are damaged and release K+ | ***Cells are damaged and release K+ | ||
***Increases the ECF K+ concentration which causes depolarization of the neuron. | ***Increases the ECF K+ concentration which causes depolarization of the neuron. |