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The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
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Am Rev Respir Dis. 1989 Jan;139(1):126-33.
 +
Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
 +
Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
 +
Source
 +
Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
 +
Abstract
 +
Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
 +
PMID: 2492170 [PubMed - indexed for MEDLINE]
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You should produce a helpful 'About Us' web page As well many websites do not invest sufficient time producing an original 'About Us' web page. Add a small spice to this webpage! Offer some insight for your visitors inform them how and why you built your web site and what goals you want it to reach for your business.
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The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
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Related citations in PubMed
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Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
 +
[Eur Respir J. 1991]
 +
Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
 +
[Chest. 1989]
 +
Lung function and exercise gas exchange in chronic heart failure.
 +
[Circulation. 1997]
 +
Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
 +
[Chest. 1993]
 +
Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
 +
[Am J Respir Crit Care Med. 1996]
 +
See reviews...
 +
See all...
 +
Cited by 9 PubMed Central articles
 +
Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
 +
[Pulm Med. 2012]
 +
Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
 +
[Am J Respir Crit Care Med. 2011]
 +
Killing the symptom without killing the patient.
 +
[Can Fam Physician. 2010]
 +
See all...
 +
Related information
 +
Related Citations
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Compound
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Compound (MeSH Keyword)
 +
Substance
 +
Substance (MeSH Keyword)
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Cited in PMC
 +
Recent activity
 +
Clear Turn Off
 +
Effects of oral morphine on breathlessness and exercise tolerance in patients wi...
 +
PubMed
 +
See more...
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You are here: NCBI > Literature > PubMedWrite to the Help Desk
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8600 Rockville Pike, Bethesda MD, 20894 USA The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
 +
Am Rev Respir Dis. 1989 Jan;139(1):126-33.
 +
Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
 +
Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
 +
Source
 +
Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
 +
Abstract
 +
Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
 +
PMID: 2492170 [PubMed - indexed for MEDLINE]
 +
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
 +
Publication Types, MeSH Terms, Substances
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The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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LinkOut - more resources
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Web site style, and running your own website, calls for your own private office space. Make your workplace space conducive to higher-top quality, efficient operate by removing distractions that could occupy your time. Keep your tools close at hand to optimize your space, and make it a lot more efficient.
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Utilize the application out there that doesn't expense you a issue when you are designing your personal website. Do not listen to people who tell you that you can't design and operate a web site with out relying on pricey computer software packages you can discover a no cost alternative for virtually every single task. Obtaining good totally free application does require a bit a lot more legwork, even so.
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View more options
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Related citations in PubMed
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Improvement platforms create the code for you, even so, they really are not as dependable as a normal text editor. The notion with a platform is that you style the web site attributes, and then paste the produced code. To decrease errors and function with the code in a a lot more hands-on way, select a common text editor.
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Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
-
 
+
[Eur Respir J. 1991]
-
Perform a thorough error check of your website, which includes checking for broken links. Do this from time to time, before uploading it to the server. If your guests cannot access the info they want because of broken links, they will get frustrated and leave. In order to stop this from occurring, proactively test thoroughly for full functionality.
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Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
-
 
+
[Chest. 1989]
-
One particular way to get a excellent domain name for your fledgling web site is by acquiring it in a domain auction. Auction websites, such as SEDO, let buy of a domain name that has already been developed. Undertaking this can help your internet site immensely. A worthwhile, top quality domain name could be pricey, but can pay key dividends to your achievement.
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Lung function and exercise gas exchange in chronic heart failure.
-
 
+
[Circulation. 1997]
-
1 of the most essential issues you can do to maintain your site functional is to make certain that all links are working correctly. A properly-created web site should always be user-friendly. Broken links are not element of a user-friendly interface. You should conduct a typical maintenance check on all of your site's links to verify they are working correctly.
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Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
-
 
+
[Chest. 1993]
-
Possessing the correct internet design is crucial. However, it can be hard to maintain up with the newest net style techniques and to make informed decisions about how to begin your efforts. The ideas above, nonetheless, are a genuinely good start off in producing sense of all that info. By employing this guidance, you can generate a lovely internet site or increase the 1 you currently have.
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Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
-
 
+
[Am J Respir Crit Care Med. 1996]
-
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See reviews...
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See all...
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Erik: Nein,ralph lauren online shop. Wobei er tats ein Faible hat, das der Platte zu Gute kommt: Er kann die Songs sehr ruhig begleiten und unterst uns nicht nur beim Spielen,lacoste, sondern gestaltet die Titel auch aktiv mit. Als es aber soweit war und der Wunsch ge wurde,nike air jordan, war es ein Schock,hollister shop. <br><br>Als nächstes wollen sie die Voraussetzungen für einen Einsatz in der Klinik zu schaffen. Für die etablierten Screeningprogramme werde eine Fehlentdeckungsrate von bis zu 20 Prozent angenommen, so die Forscher. Bei der Mammografie könnten kleinere Tumoren durch Drüsengewebe überdeckt werden und damit durch das Raster rutschen. <br><br>Telefonieren außerhalb der Inklusivleistung (inklusive Videotelefonie) in alle deutschen Netze 0,hbercrombie online shop,29 Euro/Minute. Sie dürfen den Tarif nur als Privatkunde nutzen. SMS und MMS dürfen Sie nur manuell über Ihr Endgerät erstellen. Demgegenüber ist die passive Immunisierung nach einem Zeckenstich nur eine zweitrangige Hilfsmaßnahme. Deren Wirksamkeit wird nur mit 50 bis 60 Prozent angegeben. Eine Schutzwirkung ist auch nur zu erwarten, wenn rechtzeitig mit einer ausreichend hohen Dosis geimpft wird,lacoste outlet. <br><br>Der letzte Entwurf von Star Designer Bruno Sacco stieß auf verhaltene Begeisterung. Nach dem fast filigran anmutenden 126er Coupé kam der Nachfolger zu wuchtig und unproportioniert daher,hollister shop. Eine schmale Spur ließ die 16 Zoll Alufelgen weit in die Radkästen flüchten, und auch die facettenartigen Freiform-Scheinwerfer boten keinen eleganten Anblick. <br><br>Doch so weit verbreitet diese Vorstellungen über den Gentleman sein mögen - so vage und verschwommen sind sie auch. In die Irre führen all die einschlägigen Stilfibeln und Lebenskunst-Plädoyers, die zuletzt den deutschen Buchmarkt überschwemmten. Sie haben mit der Figur des Gentlemans soviel zu tun wie, sagen wir, Erik Ode mit Roger Moore.関連記事：
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Cited by 9 PubMed Central articles
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<ul>
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Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
-
 
+
[Pulm Med. 2012]
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  <li>das sich nicht bewegen darf</li>
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Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
-
 
+
[Am J Respir Crit Care Med. 2011]
-
  <li>sondern eher f das Kopieren derselben</li>
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Killing the symptom without killing the patient.
-
 
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[Can Fam Physician. 2010]
-
  <li>korrigierte das Ganze zumindest ein bisschen</li>
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See all...
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Related information
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</ul>
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Related Citations
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Compound
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== and older people are more likely to use TV ==
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Compound (MeSH Keyword)
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Substance
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I've had great luck finding bargains on ebay: clothes, DVDs, electronics, books. However,nike free, I am in no way addicted. I'm the type to make my electronics last as long as I can. 3. I can't cook, and I'm not super adept at cleaning,uk ghd. But knowing that I live with two other people, it forces me to put shit away, to not leave food in my room, to not encourage roaches to move in and start snacking on the shit I leave around. <br><br>Be loyal,ghd iv styler. Friendship requires loyalty. Friends don't talk about each other in negative ways with others. He has more than 25 years of news reporting and editing experience at newspapers in Wisconsin and Minnesota. He served as a Pulitzer Prize juror in 2004 and 2005,high top air force ones. Gillespie has a bachelor's degree in journalism and political science from the University of Wisconsin-Madison and has been an adjunct faculty member in the School of Journalism and Mass Communication at the University of Minnesota,black nike air force. <br><br>Which you would think would translate into -- pretty good day for -- in that wildcat it so while it really don't know how to prepare -- talk about another game the Bears the Bengals both teams coming off tough losses last week the Bears. Three in two so far in the season Bengals lost that game at home to the Texans. With the Bears Chicago maybe a little cause -- can -- Matt Forte not really. <br><br>The question I left class with was, "How do we make it so that people spend a more equal amount of time looking at news that contradicts their own viewpoints as well as those that support them?" If we know that younger people are more likely to use the Internet for news, and older people are more likely to use TV, perhaps we can encourage all citizens to look for a little news each day that might counter their views. That way, it won't be so easy to engage in selective exposure and people might be exposed to differing points of view rather than only seeing their own views echoed back at them,kayano asics. I think it's time we start taking action against our tendencies toward selective exposure.
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Substance (MeSH Keyword)
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Cited in PMC
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== You may be thinking ==
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Recent activity
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Clear Turn Off
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What is unrealistic about them? Isn't 'Jack and the Beanstalk' unrealistic also?" Click, click, next comment. About "Cinderella." The mean sisters: "Can this be considered violence?" Respond: "This depends on whether it's useful to think about physical violence as a separate issue. What do the rest of you think?" Click, click. <br><br>I have been reading about Amanda Todd this week. Her story just breaks my heart and throws a spotlight on some of my unspoken, deeply buried fears. By all accounts her family was aware and tried to help her, but sometimes family isn enough. However,air force one, in the five years since programmes to combat this have been implemented,air jordan uk, the number of people doing moderate to intense physical activity increased from 9% to 39%. With a special focus on children, Visser created an island appropriate nutritional guide,nike dunk sb, and fruit and other healthy choices are now within reach,straightners ghd. more. <br><br>These were really very nice and have fitted me wonderfully. I look amazing and dashing whenever I wear the coats I purchased from your store. Thank you so much.. Several other characters are introduced way too late in the story to really make a difference. The establishment of the mad man Santa was done almost masterfully for this type of low budget eighties film. It just that once the genie is out of the bottle, the rules and reasoning evaporate, too.. <br><br>You may be thinking, "This all sounds great, but how can I ensure that a great advertisement is created to reach my target Audience?" This is where direct response media agencies come into the picture,air force ones nike. As you can tell, a lot goes into planning a successful DRTV campaign,ghd hairstraightener. You have to know where to buy the media, how to buy it at the right price, and how to make sure that an advertisement reaches a particular market..
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Effects of oral morphine on breathlessness and exercise tolerance in patients wi...
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PubMed
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== your downliners will find their own team ==
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See more...
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You are here: NCBI > Literature > PubMedWrite to the Help Desk
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Data tools help employees collect the data and analyze it efficiently,coach online. Data tools are for organizational purposes mostly. Online Analytical Processing (OLAP) is used in the analyzing process. If you wish to "isolate" your lower abs, perform the reverse crunch, where you lie on your back with your legs pointed at the ceiling. It should not be used as a substitute for professional medical advice, diagnosis or treatment. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. <br><br>WOLFMAN: No decision has been made about that as yet. CINESCAPE: When you're creating new villains for Nightwing, what type of characteristics are you looking to include? What do you think exemplifies the perfect antagonist for this hero,michael kors outlet? WOLFMAN: If I knew what made the perfect villain for Nightwing I'd create it immediately,michael kors factory outlet. I think I try to find characters who challenge his thinking process or turn his view of what things are up side down. <br><br>There are scams relating to work at home and typing online jobs have their share. Some scams are obvious and you can almost "smell" them when you see their advertisements, but others are more difficult to detect. One thing to remember is that you should ask yourself "why would anyone pay me to do that?",coach purses. <br><br>I don't think paper equity that has no tangible value will have the effect on you that you think it will,coach outlet online. You still be working harder, and you'll quickly realize that you haven't really gotten anything additional for it. In your situation, I might try to negotiate a bonus structure tied to sales of the products you've been so critical to developing.. <br><br>3. Reporting discipline. You read me rant about reporting. The easiest way to understand the principle of MLM and Avon Sales Leadership is to think of it in terms of a family tree,michael kors handbags outlet. You are the "head of the family", and anyone who joins your team will become what we call your downliners or the first generation of your family. In time, your downliners will find their own team, and your family will continue to grow through the generations.Related Articles：
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The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Am Rev Respir Dis. 1989 Jan;139(1):126-33. Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE. Source Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Abstract Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation. PMID: 2492170 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content

Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD). [Eur Respir J. 1991] Effect of naloxone on maximal exercise performance and control of ventilation in COPD. [Chest. 1989] Lung function and exercise gas exchange in chronic heart failure. [Circulation. 1997] Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. [Chest. 1993] Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. [Am J Respir Crit Care Med. 1996] See reviews... See all... Cited by 9 PubMed Central articles Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study. [Pulm Med. 2012] Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. [Am J Respir Crit Care Med. 2011] Killing the symptom without killing the patient. [Can Fam Physician. 2010] See all... Related information Related Citations Compound Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Cited in PMC Recent activity Clear Turn Off Effects of oral morphine on breathlessness and exercise tolerance in patients wi... PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search termSearch database The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch AdvancedHelp Result Filters The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to: Am Rev Respir Dis. 1989 Jan;139(1):126-33. Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease. Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE. Source Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822. Abstract Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation. PMID: 2492170 [PubMed - indexed for MEDLINE] The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control Publication Types, MeSH Terms, Substances The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control LinkOut - more resources Supplemental Content

Save items The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites View more options Related citations in PubMed Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD). [Eur Respir J. 1991] Effect of naloxone on maximal exercise performance and control of ventilation in COPD. [Chest. 1989] Lung function and exercise gas exchange in chronic heart failure. [Circulation. 1997] Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease. [Chest. 1993] Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. [Am J Respir Crit Care Med. 1996] See reviews... See all... Cited by 9 PubMed Central articles Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study. [Pulm Med. 2012] Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response. [Am J Respir Crit Care Med. 2011] Killing the symptom without killing the patient. [Can Fam Physician. 2010] See all... Related information Related Citations Compound Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Cited in PMC Recent activity Clear Turn Off Effects of oral morphine on breathlessness and exercise tolerance in patients wi... PubMed See more... You are here: NCBI > Literature > PubMedWrite to the Help Desk Simple NCBI Directory GETTING STARTED NCBI Education NCBI Help Manual NCBI Handbook Training & Tutorials RESOURCES Chemicals & Bioassays Data & Software DNA & RNA Domains & Structures Genes & Expression Genetics & Medicine Genomes & Maps Homology Literature Proteins Sequence Analysis Taxonomy Training & Tutorials Variation POPULAR PubMed Nucleotide BLAST PubMed Central Gene Bookshelf Protein OMIM Genome SNP Structure FEATURED Genetic Testing Registry PubMed Health GenBank Reference Sequences Map Viewer Human Genome Mouse Genome Influenza Virus Primer-BLAST Sequence Read Archive NCBI INFORMATION About NCBI Research at NCBI NCBI Newsletter NCBI FTP Site NCBI on Facebook NCBI on Twitter NCBI on YouTube NLM NIH DHHS USA.gov Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA

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