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| - | Am Rev Respir Dis. 1989 Jan;139(1):126-33.
| + | |
| - | Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
| + | |
| - | Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
| + | |
| - | Source
| + | |
| - | Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
| + | |
| - | Abstract
| + | |
| - | Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
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| - | Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
| + | |
| - | [Eur Respir J. 1991]
| + | |
| - | Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
| + | |
| - | [Chest. 1989]
| + | |
| - | Lung function and exercise gas exchange in chronic heart failure.
| + | |
| - | [Circulation. 1997]
| + | |
| - | Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Chest. 1993]
| + | |
| - | Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Am J Respir Crit Care Med. 1996]
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| - | See reviews...
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| - | Cited by 9 PubMed Central articles
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| - | Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
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| - | [Pulm Med. 2012]
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| - | Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
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| - | [Am J Respir Crit Care Med. 2011]
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| + | |
| - | Am Rev Respir Dis. 1989 Jan;139(1):126-33.
| + | |
| - | Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
| + | |
| - | Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
| + | |
| - | Source
| + | |
| - | Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
| + | |
| - | Abstract
| + | |
| - | Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
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| - | Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
| + | |
| - | [Eur Respir J. 1991]
| + | |
| - | Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
| + | |
| - | [Chest. 1989]
| + | |
| - | Lung function and exercise gas exchange in chronic heart failure.
| + | |
| - | [Circulation. 1997]
| + | |
| - | Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Chest. 1993]
| + | |
| - | Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Am J Respir Crit Care Med. 1996]
| + | |
| - | See reviews...
| + | |
| - | See all...
| + | |
| - | Cited by 9 PubMed Central articles
| + | |
| - | Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
| + | |
| - | [Pulm Med. 2012]
| + | |
| - | Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
| + | |
| - | [Am J Respir Crit Care Med. 2011]
| + | |
| - | Killing the symptom without killing the patient.
| + | |
| - | [Can Fam Physician. 2010]
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During the last 7 days, you had some blasts have to be redelivered because you did not return enough correct URLs one the first attempt. Partial failures really bad to our customers, so we treat these almost as badly as full failures. Please make sure you deliver blasts correctly the first time.
Your domain diversity is worse than 1 other service(s) in this category. See if you can find more domains where you can post links.
Your service is priced higher than 1 other service(s) in this category. Even if you have a better cost-per-link, it helps your Marketplace Rank to have a lower overall price. Consider offering a smaller blast: half the links for half the cost. Just make sure that doing this doesn't hurt any other measures of quality (delivery time, etc.).
Your average delivery time for a blast is 1.4 days. See if you can improve delivery times.
(Note: Some suggestions are updated approximately once every 24 hours and do not reflect changes you've made since the last update. So if you make a change, such as lowering your price, please come back tomrrow to see the impact on your Marketplace rank.) [}]
