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Histórico
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NCBI
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Skip to main content
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About NCBI Accesskeys
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The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
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Am Rev Respir Dis. 1989 Jan;139(1):126-33.
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Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
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Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
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Source
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Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
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Abstract
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Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
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PMID: 2492170 [PubMed - indexed for MEDLINE]
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The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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Publication Types, MeSH Terms, Substances
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The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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LinkOut - more resources
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Supplemental Content
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Save items
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The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
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View more options
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Related citations in PubMed
+
-
Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
+
-
[Eur Respir J. 1991]
+
-
Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
+
-
[Chest. 1989]
+
-
Lung function and exercise gas exchange in chronic heart failure.
+
-
[Circulation. 1997]
+
-
Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
+
-
[Chest. 1993]
+
-
Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
+
-
[Am J Respir Crit Care Med. 1996]
+
-
See reviews...
+
-
See all...
+
-
Cited by 9 PubMed Central articles
+
-
Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
+
-
[Pulm Med. 2012]
+
-
Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
+
-
[Am J Respir Crit Care Med. 2011]
+
-
Killing the symptom without killing the patient.
+
-
[Can Fam Physician. 2010]
+
-
See all...
+
-
Related information
+
-
Related Citations
+
-
Compound
+
-
Compound (MeSH Keyword)
+
-
Substance
+
-
Substance (MeSH Keyword)
+
-
Cited in PMC
+
-
Recent activity
+
-
Clear Turn Off
+
-
Effects of oral morphine on breathlessness and exercise tolerance in patients wi...
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-
PubMed
+
-
See more...
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-
You are here: NCBI > Literature > PubMedWrite to the Help Desk
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Simple NCBI Directory
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GETTING STARTED
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NCBI Education
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NCBI Help Manual
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NCBI Handbook
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Training & Tutorials
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RESOURCES
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Chemicals & Bioassays
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Data & Software
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DNA & RNA
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Domains & Structures
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Genes & Expression
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Genetics & Medicine
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Genomes & Maps
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Homology
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Literature
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Proteins
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Sequence Analysis
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Taxonomy
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Training & Tutorials
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Variation
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POPULAR
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PubMed
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Nucleotide
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-
BLAST
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PubMed Central
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Gene
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Bookshelf
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Protein
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OMIM
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Genome
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SNP
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Structure
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FEATURED
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Genetic Testing Registry
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PubMed Health
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GenBank
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Reference Sequences
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Map Viewer
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Human Genome
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Influenza Virus
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Primer-BLAST
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Sequence Read Archive
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NCBI INFORMATION
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About NCBI
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NLM NIH DHHS USA.gov
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Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact
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National Center for Biotechnology Information, U.S. National Library of Medicine
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8600 Rockville Pike, Bethesda MD, 20894 USA The following menu user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
+
-
NCBI
+
-
Skip to main content
+
-
Skip to navigation
+
-
Resources
+
-
How To
+
-
About NCBI Accesskeys
+
-
Sign in to NCBI
+
-
PubMed
+
-
US National Library of Medicine National Institutes of Health
+
-
Search termSearch database
+
-
The following autocomplete user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSearch
+
-
AdvancedHelp
+
-
Result Filters
+
-
The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlDisplay Settings:AbstractThe following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlSend to:
+
-
Am Rev Respir Dis. 1989 Jan;139(1):126-33.
+
-
Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
+
-
Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
+
-
Source
+
-
Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
+
-
Abstract
+
-
Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
+
-
PMID: 2492170 [PubMed - indexed for MEDLINE]
+
-
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
+
-
Publication Types, MeSH Terms, Substances
+
-
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
+
-
LinkOut - more resources
+
-
Supplemental Content
+
-
 
+
-
Save items
+
-
The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
+
-
View more options
+
-
Related citations in PubMed
+
-
Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
+
-
[Eur Respir J. 1991]
+
-
Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
+
-
[Chest. 1989]
+
-
Lung function and exercise gas exchange in chronic heart failure.
+
-
[Circulation. 1997]
+
-
Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
+
-
[Chest. 1993]
+
-
Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
+
-
[Am J Respir Crit Care Med. 1996]
+
-
See reviews...
+
-
See all...
+
-
Cited by 9 PubMed Central articles
+
-
Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
+
-
[Pulm Med. 2012]
+
-
Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
+
-
[Am J Respir Crit Care Med. 2011]
+
-
Killing the symptom without killing the patient.
+
-
[Can Fam Physician. 2010]
+
-
See all...
+
-
Related information
+
-
Related Citations
+
-
Compound
+
-
Compound (MeSH Keyword)
+
-
Substance
+
-
Substance (MeSH Keyword)
+
-
Cited in PMC
+
-
Recent activity
+
-
Clear Turn Off
+
-
Effects of oral morphine on breathlessness and exercise tolerance in patients wi...
+
-
PubMed
+
-
See more...
+
-
You are here: NCBI > Literature > PubMedWrite to the Help Desk
+
-
Simple NCBI Directory
+
-
GETTING STARTED
+
-
NCBI Education
+
-
NCBI Help Manual
+
-
NCBI Handbook
+
-
Training & Tutorials
+
-
RESOURCES
+
-
Chemicals & Bioassays
+
-
Data & Software
+
-
DNA & RNA
+
-
Domains & Structures
+
-
Genes & Expression
+
-
Genetics & Medicine
+
-
Genomes & Maps
+
-
Homology
+
-
Literature
+
-
Proteins
+
-
Sequence Analysis
+
-
Taxonomy
+
-
Training & Tutorials
+
-
Variation
+
-
POPULAR
+
-
PubMed
+
-
Nucleotide
+
-
BLAST
+
-
PubMed Central
+
-
Gene
+
-
Bookshelf
+
-
Protein
+
-
OMIM
+
-
Genome
+
-
SNP
+
-
Structure
+
-
FEATURED
+
-
Genetic Testing Registry
+
-
PubMed Health
+
-
GenBank
+
-
Reference Sequences
+
-
Map Viewer
+
-
Human Genome
+
-
Mouse Genome
+
-
Influenza Virus
+
-
Primer-BLAST
+
-
Sequence Read Archive
+
-
NCBI INFORMATION
+
-
About NCBI
+
-
Research at NCBI
+
-
NCBI Newsletter
+
-
NCBI FTP Site
+
-
NCBI on Facebook
+
-
NCBI on Twitter
+
-
NCBI on YouTube
+
-
NLM NIH DHHS USA.gov
+
-
Copyright | Disclaimer | Privacy | Browsers | Accessibility | Contact
+
-
National Center for Biotechnology Information, U.S. National Library of Medicine
+
-
8600 Rockville Pike, Bethesda MD, 20894 USA
+
-
 
+
-
== meanwhile ==
+
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+
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When this is belched back up it often smells odorous due to those gases,true religion jeans outlet. The same thing happens whenever this air or gas is passed downward, first through the small intestine, and then the large intestine and out through the rectum. This air is then called flatulence.. <br><br>As women, we can spend years not decades our of desire and passion inside of us. We hold our Big Ideas, dreams, and goals at our core because we are nurturers by nature and put others needs ahead of ourselves. We give care and support to family, friends, colleagues, and community. <br><br>In closets spring air adjustable bed or is it to improve the phone,true religion sale. Along with aches and the shape of the bathroom spring air adjustable bed to feel confused or hard 21. Services time when spring air adjustable bed mankind did you if you want to various positions,true religion jeans. <br><br>As it was already said Medical Air Mattresses were made according to the latest technologies and they are also made according to all standards for hospital beds. Any patient can use them. One limit is the weight of a patient: the maximum possible weight is 350 lbs. <br><br>Not everyone who loves pool has the room to keep a table up all the time. Full-size pool tables require a lot more room than their footprints, which is why experts recommend a five-foot buffer all the way around to account for shots right on the rail. Needless to say, that's a pretty sizable commitment for any room.. <br><br>This week at the International Toy Fair in New York City the new Star Wars Toys arrived. It wasn the full onslaught of products we here at Mania are used to seeing. In fact, it may have been the smallest amount of toys this Toy Maniac has seen in years. <br><br>Knockmore, meanwhile,true religion sale, have taken a different approach. Their motion suggests that 'the County Senior League be restructured into divisions consisting of eight teams based on the positions in which teams finished in the 2012 Senior League,cheap true religion jeans. Each division would play seven home games and seven away games with Rounds 1 to 7 being the reverse of Rounds 8 to 14,cheap true religion jeans.Related Articles：
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  <li>tips for homeschooling</li>
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  <li>wildlife preserve and public beach</li>
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</ul>
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== and unsoiled fun ==
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<ul>
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  <li>grandmother</li>
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  <li>in theaters</li>
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  <li>and its consequences</li>
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</ul>
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Current revision as of 00:51, 11 September 2017

Histórico

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