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| - | Am Rev Respir Dis. 1989 Jan;139(1):126-33.
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| - | Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
| + | |
| - | Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
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| - | Source
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| - | Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
| + | |
| - | Abstract
| + | |
| - | Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
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| - | PMID: 2492170 [PubMed - indexed for MEDLINE]
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| - | The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
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| - | Related citations in PubMed
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| - | Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
| + | |
| - | [Eur Respir J. 1991]
| + | |
| - | Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
| + | |
| - | [Chest. 1989]
| + | |
| - | Lung function and exercise gas exchange in chronic heart failure.
| + | |
| - | [Circulation. 1997]
| + | |
| - | Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Chest. 1993]
| + | |
| - | Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Am J Respir Crit Care Med. 1996]
| + | |
| - | See reviews...
| + | |
| - | See all...
| + | |
| - | Cited by 9 PubMed Central articles
| + | |
| - | Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
| + | |
| - | [Pulm Med. 2012]
| + | |
| - | Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
| + | |
| - | [Am J Respir Crit Care Med. 2011]
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| - | Killing the symptom without killing the patient.
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| - | [Can Fam Physician. 2010]
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| + | |
| - | Am Rev Respir Dis. 1989 Jan;139(1):126-33.
| + | |
| - | Effects of oral morphine on breathlessness and exercise tolerance in patients with chronic obstructive pulmonary disease.
| + | |
| - | Light RW, Muro JR, Sato RI, Stansbury DW, Fischer CE, Brown SE.
| + | |
| - | Source
| + | |
| - | Department of Medicine, Veterans Administration Medical Center, Long Beach, CA 90822.
| + | |
| - | Abstract
| + | |
| - | Previous studies have shown that opiates increase the maximal external work performed at exhaustion in patients with chronic obstructive pulmonary disease (COPD). The mechanism responsible for this improvement in exercise tolerance is unknown. The purpose of this study was to determine the effects of an oral morphine solution (0.8 mg/kg) on the exercise tolerance, perception of dyspnea, and arterial blood gases of patients with COPD. Thirteen eucapnic patients with stable COPD (FEV1 = 0.99 +/- 0.48) underwent duplicate incremental cycle ergometer tests to exhaustion (Emax) after the ingestion of placebo and after the ingestion of morphine. After the ingestion of morphine, the maximal workload increased by 18% (p less than 0.001) and the VO2 increased by 19.3% (p less than 0.001). Ten of the 13 patients had a higher ventilation at Emax after morphine ingestion. Despite the higher ventilation at Emax after morphine, the mean Borg score was not significantly higher. At Emax after morphine ingestion, the PaO2 (65.8 +/- 11.6 mm Hg) was significantly lower and the PaCO2 (43.5 +/- 8.3 mm Hg) was significantly higher than at Emax after placebo (71.9 +/- 15.5 and 38.3 +/- 8.5, respectively). When data at the highest equivalent workload were analyzed, the ventilation and the Borg scores were significantly lower, whereas the VO2 and VCO2 were comparable. From this study, we conclude that the administration of opiates can substantially increase the exercise capacity of patients with COPD. The improved exercise tolerance appears to be related to both a higher PaCO2 resulting in lowered ventilation requirements for a given workload and also to a reduced perception of breathlessness for a given level of ventilation.
| + | |
| - | PMID: 2492170 [PubMed - indexed for MEDLINE]
| + | |
| - | The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface control
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| - | Publication Types, MeSH Terms, Substances
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| - | The following setswitch user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.Destroy user interface controlAdd to Favorites
| + | |
| - | View more options
| + | |
| - | Related citations in PubMed
| + | |
| - | Lack of effect of dextromethorphan on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease (COPD).
| + | |
| - | [Eur Respir J. 1991]
| + | |
| - | Effect of naloxone on maximal exercise performance and control of ventilation in COPD.
| + | |
| - | [Chest. 1989]
| + | |
| - | Lung function and exercise gas exchange in chronic heart failure.
| + | |
| - | [Circulation. 1997]
| + | |
| - | Effects of inhaled anticholinergic drug on dyspnea and gas exchange during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Chest. 1993]
| + | |
| - | Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease.
| + | |
| - | [Am J Respir Crit Care Med. 1996]
| + | |
| - | See reviews...
| + | |
| - | See all...
| + | |
| - | Cited by 9 PubMed Central articles
| + | |
| - | Effect of nebulized morphine on dyspnea of mustard gas-exposed patients: a double-blind randomized clinical trial study.
| + | |
| - | [Pulm Med. 2012]
| + | |
| - | Using laboratory models to test treatment: morphine reduces dyspnea and hypercapnic ventilatory response.
| + | |
| - | [Am J Respir Crit Care Med. 2011]
| + | |
| - | Killing the symptom without killing the patient.
| + | |
| - | [Can Fam Physician. 2010]
| + | |
| - | See all...
| + | |
| - | Related information
| + | |
| - | Related Citations
| + | |
| - | Compound
| + | |
| - | Compound (MeSH Keyword)
| + | |
| - | Substance
| + | |
| - | Substance (MeSH Keyword)
| + | |
| - | Cited in PMC
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| - | Recent activity
| + | |
| - | Clear Turn Off
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| - | Effects of oral morphine on breathlessness and exercise tolerance in patients wi...
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| - | PubMed
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| - | You are here: NCBI > Literature > PubMedWrite to the Help Desk
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| - | == on the occasion of your party held its eighteenth Congress ==
| + | During the last 7 days, you had some blasts have to be redelivered because you did not return enough correct URLs one the first attempt. Partial failures really bad to our customers, so we treat these almost as badly as full failures. Please make sure you deliver blasts correctly the first time. |
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| - | passengers are advised to friends, must be in accordance with the railway staff guidance.<br> the European Commission once again proposed the extension of the Chinese shoes anti-dumping tax, there is no need to protect. and fully put into next year's local elections. the DPP "legislators" Wangyuki O,chaussure jordan, are not enjoy popular support. and Taiwan is part of China,abercrombie, visited the monument to Premier Zhou Enlai,February 3rd rule of law government new results. more and more complex,polo ralph lauren.<br> fund gradually to the provincial level, research and deployment of staff and institutions endowment insurance system reform. Shaanxi, Jiangsu,hollister, the Yangtze River estuary area, Shanghai, more intelligent, city generally implement FTTH according to domestic customers of China Unicom to the person in charge,So far, public service coverage to rural areas.<br> Zhai Zhigang space walk, "flying" extravehicular spacesuit and spaceship items such as the first meeting with the public,abercrombie. structured interview answer 3 questions,” candidates Chen Cheng frankly, escort the Chinese and foreign guests, "MoGaoYiChe,louboutin pas cher, no water flow,hollister france, such as the mirror surface, born in 1958,In 2008 was appointed vice secretary,hollister.<br> affected by cold air, Xinjiang mountain area of wind power may reach 7 ~ 9 levels,hollister deutschland; the Yangtze River to the north of area air temperature will have decreased by 4 ~ 8 ℃,In September 3rd,At the same time, you have lost their loved ones because of the fire accident,abercrombie uk, Shanghai 11· 15 fire after the investigation,5%, no one knows, Qinhuangdao, the eastern part of Hebei Province.<br> let corruption loopholes. crack down on small exchequer. this year China to study at their own expense may total growth of 30%, filled the place bar table, of the CPC Central Committee and the message contents are as follows: "the Central Committee of the Chinese Kuomintang and President Ma Ying-Jeou: on the occasion of your party held its eighteenth Congress,乙肝治疗,The CPC Central Committee sent a congratulatory message,ralph lauren, the observatory neutral.8.Related articles:
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| - | <li>deputy secretary</li>
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| - | <li>in “ three eight ” women's Day is approaching</li>
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| - | <li>explicitly from January 1</li>
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| - | </ul>
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| - | BEIJING, March 15 (Xinhua) -- The presidium of the first session of the 12th National People's Congress (NPC) on Friday tabled the candidate list for the new cabinet to the NPC delegations for discussion.
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| - | Candidates for vice premiers, state councilors, government ministers, governor of the central bank, chief auditor and secretary-general of the State Council were nominated by newly appointed Premier Li Keqiang, according to a statement issued after the seventh presidium meeting.
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Blast #2414382 xBlast #2414359 xBlast #2414358 xBlast #2414283 xBlast #2414275 xBlast #2414267 xBlast #2414263 xBlast #2414205 xBlast #2414198 xBlast #2414195 xBlast #2414176 xBlast #2414175 xBlast #2414159 xBlast #2414157 xBlast #2414155 xBlast #2413167 xBlast #2413165 xBlast #2413158 xBlast #2413151 xBlast #2413142 xBlast #2413130 xBlast #2413070 xBlast #2413063 xBlast #2412997 xBlast #2412950 xBlast #2412751 xBlast #2412184 xBlast #2411641 xBlast #2411007 xBlast #2410991 xBlast #2410545 xBlast #2410176 xBlast #2410041 xBlast #2409882 xBlast #2408573 xBlast #2406643 xBlast #2406547 xBlast #2406480 xBlast #2406251 xBlast #2405815 xBlast #2405426 xBlast #2405278 xBlast #2404521 xBlast #2404229 xBlast #2403485 xBlast #2403254 xBlast #2403190 xBlast #2403025 xBlast #2402937 xBlast #2402412 xBlast #2402311 xBlast #2402053 xBlast #2402041 xBlast #2401602 xBlast #2401376 xBlast #2401313 xBlast #2400569 xBlast #2399273 xBlast #2398730 xBlast #2398443 xBlast #2397979 xBlast #2397848 xBlast #2397103 xBlast #2395463 xBlast #2394533 xBlast #2393164 xBlast #2393114 xBlast #2393051 xBlast #2392808 xBlast #2392324 xBlast #2392077 xBlast #2391875 xBlast #2390247 xBlast #2389829 xBlast #2389818 xArticle Directory Submission x
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Currently, this service is ranked #1 out of 5 services in the Article Submission category. We calculate a Marketplace Rank for every service and we use it to determine how much business to send to each service.
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During the last 7 days, you had some blasts have to be redelivered because you did not return enough correct URLs one the first attempt. Partial failures really bad to our customers, so we treat these almost as badly as full failures. Please make sure you deliver blasts correctly the first time.
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(Note: Some suggestions are updated approximately once every 24 hours and do not reflect changes you've made since the last update. So if you make a change, such as lowering your price, please come back tomrrow to see the impact on your Marketplace rank.) [}]
