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Businessagency on March 20th news editor true church events for many Chinese first learned about the extract bear bile industry ,and this line of business should be listed for the first time to become a universal topic .
&nbsp  ;argumentative focus from whether to maintain the special status of traditional Chinese medicine ,,to should establish what kind of animal protection ,to western medicine conspiracy theory etc.
,moncler pas cher.&nbsp  ;the Securities Times reporter investigates the discovery ,bear the effective components of ursodeoxycholic acid production is not monopoly of foreign companies ,domestic ursodeoxycholic acid are but embarrassed  : on the one hand is the traditional Chinese medicine in China ingrained ursodeoxycholic acid price on the low side ,a narrow  ;on the other hand is foreign pharmaceutical companies in the domestic market to obtain higher pricing at the same time ,the bulk purchase of domestic digest cheap raw materials .
Put aside to extract bear bile moral judgment and medicine quality evaluation, homebred ursodeoxycholic acid how to walk out of predicament is perhaps more urgent problems at present .&nbsp  ;Qingdao Star Trading International Trade Limited company boss Liu Xinan is a busy man, March 14th early in the morning he flew from Qingdao to Beijing with a business partner .
The meeting place is chosen in BeiJing Capital Airport ,after talking about things ,he was flying from Beijing to Qingdao .By 7 p.m., the Securities Times reporter dials his telephone .&nbsp  ;&ldquo  ;domestic ursodeoxycholic acid production has 10 years of history .
&rdquo  ;spoke to Liu Xinan full of air ,can the date line 1500 kilometers tired .Liu Xin of ursodeoxycholic acid is western medicine confirmed in bear bile is the main active ingredient ,at present by Qingdao monthly star export to foreign ursodeoxycholic acid is about 3 tons ,while the domestic pharmaceutical production approval and certification through the national GMP manufacturers ursodeoxycholic acid is about 4,.
5 tons per month .&nbsp  ;compared with ursodeoxycholic acid ,Chinese people are more familiar with the bear .Bear bile ,strictly refers to black or brown bear gallbladder ,,TCM believes that it can be heat-clearing and detoxifying ,Mingmu ,antispasmodic ,in Chinese medicine application, bear as a drug ,has been for thousands of years .
With high medicinal value ,kill the bear bile once caused Asian wild bear declines .On 1988, Ministry of Health issued on the order of &ldquo  ;drainage bear gall &rdquo  ;Interim Measures for the administration of the notice ,,make artificial draining bear bile dry goods can be used as natural bear alternative medicine, and temporarily named &ldquo  ;&rdquo ,bear bile powder  ;to distinguish it from natural bear gall .
&nbsp  ;thereafter ,including the true church ,extract bear bile enterprise vigorous development .According to the China Association of traditional Chinese medicine ,said Fang Shuting ,currently a total of 68 legitimate bear farms ,quantity of amount of livestock on hand exceeds 10000, the desirable bear the amount is about 6000 to 8000 .
Although the true church in the size of the bear farms industry is not the biggest, but the first attempt to land do poineering work board extract bear bile enterprises .&nbsp  ;coincidentally ,the largest domestic ursodeoxycholic acid pharmaceutical raw materials producers Braun Zhongshan biological technology limited company founder Zhang Heping gem with some sources .
On 2001, Zhang Heping from a Shenzhen pharmaceutical enterprises to join a Vc firms ,as the pharmaceutical industry investment manager ,want to finance capital identity into gem gold tide ,but then the gem launch conditions are not ripe .
In 2004, Zhang Heping left the investment company ,initiated the establishment of the Zhongshan lark biological technology limited company ,ursodeoxycholic acid is one of the main products of the company .
In 2005, Zhongshan Braun was the cornerstone of Shenzhen venture capital Cci Capital Ltd about 3000000 yuan ,now ,Zhongshan Braun has occupied the domestic ursodeoxycholic acid into nearly six market share ,.
&nbsp  ;ursodeoxycholic acid UDCA ,1927 by the Japanese first from Chinese gall bladders were isolated in 1937 to determine its structure ,crystallization ,1957 was closed loading JP ,Western Medicine concluded that ursodeoxycholic acid is the most effective composition of bear gall .
In our country, subject to the drug pricing policy ,consumption habits and approved by the state of ursodeoxycholic acid in the range of indications and other factors, ursodeoxycholic acid in the domestic preparation very low prices ,market space is very narrow .
At the same time ,the market has also been overseas preparation plant sexy beast ,michael kors outlet,domestic ursodeoxycholic acid industry live the current situation is rather embarrassing .&nbsp  ;&nbsp product spreads tens of times  ;ursodeoxycholic acid industry scale is 210000000 &nbsp  ;poultry bile is domestic manufacturer producing ursodeoxycholic acid is the main raw material ,the monthly output of about 2000 tons of poultry bile .
Making method includes poultry bile into bile paste ,extracted ursodeoxycholic acid is the main raw material of chenodeoxycholic acid ,followed by a change of chenodeoxycholic acid molecular structure made of ursodeoxycholic acid .
&nbsp  ;Zhang Heping to reporters just a dead ,&ldquo  ;1 tons of poultry bile can be made about 20 kg of chenodeoxycholic acid ,and further to about 15 kg of ursodeoxycholic acid .Now 1 tons of raw materials is about 12000 yuan ,so doing ,ursodeoxycholic acid is the main raw material for poultry bile a cost about 900 yuan / kg .
Considering the other raw material cost ,manufacturing cost ,management cost and small profits ,ursodeoxycholic acid market price is about 2400 yuan / kg .&rdquo  ;and understand according to the reporter to the data ,the extract bear bile method to obtain high quality of bear bile powder market price of about 5000 yuan to 8000 yuan / kg .
Therefore ,according to the unit price ,formed between 2 to 3 times the price .&nbsp  ;further specific to the drug material downstream of the preparation link, extract bear bile and bear bile powder ursodeoxycholic acid raw material price is more obvious .
As a result of ursodeoxycholic acid preparations have been included in the basic drug list ,moncler,price is determined by the state ,currently on the market mainstream of ursodeoxycholic acid preparation by effective component of ursodeoxycholic acid in calculation ,the retail price of about 6 yuan per gram .
In contrast ,in order to extract bear bile production of bear gall powder in the consumer market sales price of about 120 yuan per gram .According to the Pharmacopoeia ,bear bile powder taurine ursodeoxycholic acid content is greater than 30% ,converted to ursodeoxycholic acid content is approximately 25% .
If ursodeoxycholic acid the effective components of computing ,terminal bear bile powder products of ursodeoxycholic acid price over 400 yuan per gram .Obviously, to the effective component to measure the western medicine and Chinese traditional medicine of ursodeoxycholic acid preparation of bear bile powder price gap of up to tens of times .
&nbsp  ;not only that ,even if only in the western context ,because the country is right of import and domestic drug pricing in different ways ,imported products than the domestic ursodeoxycholic acid preparation to higher prices many times .
Reporters access to data, the import of ursodeoxycholic acid preparation mainly from Germany ,Italy and South Korea ,manufacturers including German Fokker big pharma ,Italy Besty pharmaceutical and Korean bear Pharmaceutical Co Ltd .
Also in accordance with the active ingredient is calculated, the imported ursodeoxycholic acid per gram of unit in 40 to 60 yuan range of fluctuations .&nbsp  ;Zhang Heping, former domestic production of ursodeoxycholic acid raw materials on quality of similar foreign products and the existence of small gap ,abercrombie france,but in recent years ,the domestic production of ursodeoxycholic acid raw material quality has made breakthrough progress ,Zhongshan bailing production of ursodeoxycholic acid has not only with the Chinese Pharmacopoeia standards ,but also in line with Europe and the United States and Japan market requirement .
Therefore ,domestic and foreign agents preparation the huge price difference is not derived from the quality gap ,mainly derived from the brand gap and domestic pricing mechanism .&nbsp ,moncler;at low prices at the same time ,moncler,ursodeoxycholic acid and its preparation industry scale is not big .
At present, domestic ursodeoxycholic acid annual capacity of about 100 tons ,the actual output is only around 50 tons ,according to 2400 yuan / kg of market prices ,the total size of about 120000000 yuan .
Plus domestic downstream agents manufacturers ,according to the annual procurement of 15 tons of ursodeoxycholic acid ,preparation market size also is 90000000 yuan only ,the two together ,ursodeoxycholic acid industry overall sales in the domestic income of only 210000000 yuan .
This volume relative to extract bear bile industry ,may be just a drop in the bucket .Data shows ,China now has 68 domestic enterprises to bear ,abercrombie,123 kinds of proprietary Chinese medicine products ,183 downstream enterprises ,the bear farming industry output value reached about 10000000000 yuan .
Even if Shanghai Kai ( 300039) a company ,to bear bile powder as the main raw materials of Tanreqing Injection in the first half of 2011 to obtain business income 390000000 yuan .Visible home ursodeoxycholic acid in the entire industry sales revenue only and Shanghai Kai Bao a product 1/4 .
&nbsp  ;domestic market to restrict multiple &nbsp  ;overseas preparation plant or into a big winner &nbsp  ;low price theory should contribute to the product demand ,but the actual situation is not so .
Shanghai Heng Mountain Pharmaceutical Company Limited is the National more than 30 with ursodeoxycholic acid preparation approval of one of the manufacturers ,but due to weak demand, the current production of ursodeoxycholic acid preparation manufacturers only about 10 .
&nbsp  ;Shanghai Heng Mountain production director Zhu Wenjie told the reporters  :&ldquo  ;the actual situation now is ,in order to support drug treatment, the phenomenon is still very common .
In this case ,the low price drugs opens the market very hard .Sometimes even the bid, the hospital did not buy .Although this is a good product ,but demand has been to go up not to go ,now insist on the production of about 10 enterprises,abercrombie france, only barely production this variety of manufacturers ,because the quantity is too small, simply raise not vivid enterprise .
&rdquo  ;&nbsp ,doudoune moncler;but the extract bear bile downstream bear bile powder preparation industry and imported products ,can obtain higher pricing .Zhu Wenjie said  :&ldquo  ;traditional Chinese medicine prices are relatively high ,demand is relative bigger reason is long-term since drug habits .
Now the hepatobiliary drugs mainly the domestic medicine, and traditional Chinese medicine emphasizes the purity of raw materials ,long-term culture and culture cause consumers favor extract bear bile products .
In addition ,herbal products pricing transparency than western medicine ,traditional Chinese medicine products because of high prices, is more prone to seize the hospital channel .The high price of imported formulations ,by hospital channel favor ,this compression of ursodeoxycholic acid preparation living space .
&rdquo  ;&nbsp  ;apparently ,domestic ursodeoxycholic acid and its preparation industry faces a price to go up not to go ,also put out of embarrassment .In the preparation of short-term inside cannot break through the bottleneck case ,ursodeoxycholic acid raw material medicine enterprises choose the export market .
Last year, countrywide ursodeoxycholic acid production is 50 tons ,domestic consumption is only 15 tons ,the rest are all exported to foreign .Liu Xinan tells a reporter  :&nbsp  ;&ldquo  ;at present the domestic market of ursodeoxycholic acid demand less ,so that price may offer some exports ,export about 2200 yuan / kg look ,now the overseas mainstream market price is about $360 to $400 / kg .
So from the Chinese market imports of ursodeoxycholic acid ,price may be lower than in similar overseas cheap $50 to $100 / kg .&rdquo  ;&nbsp  ;Liu Xinan forecast ,abercrombie,in recent years our country of ursodeoxycholic acid in the export volume will be further growth ,with annual export 85 tons of ursodeoxycholic acid ,every kilogram cheap at $50 ,imports from China of ursodeoxycholic acid for overseas manufacturers to annual savings of more than 25000000 yuan .
It is understood ,in overseas ursodeoxycholic acid preparation product profit is relatively high ,from the domestic exports of ursodeoxycholic acid raw materials in overseas only 30% remaining for the pharmaceutical ,used in the manufacture of health care products ,but the production of drugs out to create profit almost health products and quite .
Preparation of high profit imported phenomena are likely to appear in the domestic large-scale .Public data shows ,Korea bear about Korea has about 90% of ursodeoxycholic acid market .Understand according to the reporter ,South Korea bear has applied for Chinese drug regulatory departments located the Korean factory certification ,once certified, Korea bear of ursodeoxycholic acid preparations will be large-scale enter home .
&nbsp  ;according to Liu Xinan ,is currently South Korea has more than 60% of the raw materials of chenodeoxycholic acid from Chinese imports .The data shows ,the future overseas manufacturers will be through a large number of cheap imported raw materials in China ,,the mainland after processing Fanxiao Chinese market ,raw material price is exactly the same Chinese products dozens of times over .
In fact ,ursodeoxycholic acid preparation drug imports in the domestic market share is very high .2011, countrywide ursodeoxycholic acid formulation corresponding ursodeoxycholic acid active ingredient consumption is 30 tons ,of which 15 tons of domestic manufacturers use .
That is to say ,in terms of the number of imported drugs occupy nearly half the market price  ;and because of the huge gap, in sales in more than 90% of the market by import agents occupy ,doudoune moncler pas cher.
With the domestic ursodeoxycholic acid raw materials enterprises to domestic demand expansion ,preparations continued sluggish and imported products to speed up to enter the domestic market rate ,the future of ursodeoxycholic acid preparation will likely lose domestic ursodeoxycholic acid Market initiative .
&nbsp  ;long xiongtu road in He Fang  ?&nbsp  ;although ursodeoxycholic acid as raw material and preparation in the domestic situation is awkward, but those within the sector in the future full of imagination .
Data shows ,the world of ursodeoxycholic acid in the annual demand of about 1000 tons ,each year about 15% growth .Although the Japanese population is much smaller than that of China ,but Japan consumption of ursodeoxycholic acid up to 300 tons ,the annual consumption of ursodeoxycholic acid in South Korea is also up to 100 tons of above .
&nbsp  ;cornerstone venture currently holds a 22% stake in Zhongshan lark ,and the presence of directors .Partner ,President Wang Qiwen said in an interview  :&ldquo  ;we help Zhongshan lark and solve some poultry bile supply problems,moncler, Zhongshan Braun plan 2012 capacity doubled again, next we hope to the preparation of extension .
&rdquo  ;&nbsp  ;and the foundation of venture capital is similar ,many industry insiders also optimistic about the future hope of ursodeoxycholic acid has made great development .Liu Xinan told the reporters  :&ldquo  ;I believe it will replace extract bear bile ,traditional Chinese medicine experts may think this thing is not authentic, that cannot be substituted ,but from a therapeutic perspective, there is no doubt that can completely replace .
&rdquo  ;&nbsp ,doudoune moncler;but objectively speaking ,ursodeoxycholic acid problem facing the industry is still very grim .One of them is the national price is low ,difficult to obtain hospital channel support .
Zhu Wenjie said  :&ldquo  ;the main problem is national price is too low ,Chinese medicine effective constituents of traditional Chinese medicine and Western medicine is the same ,but due to different system ,,two kinds of drug price gap is big .
And now for a dosage form to raise the price of the method is not very strict ,state regulation .&rdquo  ;&nbsp  ;in addition to change the dosage form ,containing the new drug R & D ursodeoxycholic acid is also a theoretical approach ,because the drug can often get the pricing mechanism of the tilt ,make production enterprises better benefits .
But for using ursodeoxycholic acid and other ingredients together the preparation of artificial bear bile powder to replace natural bear bile powder ,in Zhang Heping ,the need to do a lot of research ,but the fund and time devoted to current industry of any enterprise is unable to assume ,by individual enterprises do not reality .
&nbsp  ;another aspect is the drug marketing .Chinese medicine of bear bile powder by the preservation of culture and tradition which is widely accepted by the patients ,but the ursodeoxycholic acid for many consumers are strange .
The cause of this situation is one of the main reasons for domestic ursodeoxycholic acid preparations in the domestic sales are generally use the name rather than the name of commodity ,preparations are not willing to invest substantial resources to promote .
In addition to the entire industry was on a small scale ,single enterprise is difficult to come up with a large funds for marketing .&nbsp  ;the extract bear bile downstream of the injection, 2004 product market sales of 17000000 yuan, with 2 years of time only achieved 200000000 yuan sales income .
&nbsp  ;in an interview with reporters in the process, regardless of dosage form manufacturers ,traders ,pharmaceutical raw materials producers and venture capital are specifically mentioned the necessity to strengthen the drug marketing .
But they need to face will be long-term since patients consumption habits ,the traditional Chinese medicine culture puissant nick .It will again be involved in learning whether the listing hall ,biochemical synthesis should replace extract bear bile sensitive topics .
&nbsp  ;be in a nice hobble to the situation ,Zhu Wenjie said  :&ldquo  ;wait for the state to ursodeoxycholic acid price is not possible, we expect the country continues to advance reform ,ban drug-maiataining-medicine ,so that in the vast rural market ,ursodeoxycholic acid has a chance .
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particularly Medicare extended surface standard

&nbsp  ;&nbsp  ;&nbsp  ;&nbsp  ;&nbsp  ;&nbsp  ;&nbsp  ;&nbsp  ;business agency on November 16th dispatch of essential medicine system in China carries out two years many ,experts and scholars on the Huimin policy how to treat  ?What aspects need to be improved  ?Should be how to do  ?The reporter interviewed the Peking University China Economic Research Center Deputy Director Li Ling .
&nbsp  ;Li Ling says ,michael kors outlet,our country implements the basic drug system ,is more complex than other countries ,doudoune moncler pas cher.This is because ,our medical and health system is rapidly changing ,especially in the pharmaceutical industry in our country is still in the &ldquo ,;small ,scattered ,chaotic &rdquo  ;the primary stage of development ,the medical service system has not realized the public welfare ,to implement the basic drug system in many external conditions are not perfect .
&nbsp  ;&ldquo  ;essential drugs system ,even on the pharmaceutical industry ,under the joint medical service system .The current people feel the basic drug system brings some problems,, essence is the pharmaceutical industry and medical service system of long-term accumulation of problems in basic medicine system on the performance of .
&rdquo ,;Li Ling said .&nbsp  ;Li Ling argues that complexity is mainly manifested in the following aspects  :&nbsp  ;&mdash  ;&mdash  ;essential medicine system in China also have a drug supply and medical protection function ,moncler.
Although China has already set up the medical security system ,but the medical insurance efficiency is not high ,medical service and drug supply structure is not reasonable ,appropriate technology ,suitable drug supply is insufficient, excessive drug use ,irrational drug use is very serious .
Therefore ,,China drug system ,not only economically relieve patients much burden ,more important is to see in advance appropriate medication ,transformation of medical model ,improve and standardize the drug quality plays a profound role .
&nbsp  ;&mdash  ;&mdash  ;essential medicine system in China plays a key role in the reform of medical health .Through the implementation of essential drug system ,abercrombie france,move the operation mechanism of medical institutions reform ,solve the excessive medical treatment in hospital ,in order to support drug treatment ,reverse doctor motivation mechanism .
If these problems are not solved ,the basic drug system will not be implemented ,even with the implementation of people do not benefit .From our country old reform course and primary health care experience,, only from the cancellation of drug-maiataining-medicine proceed with, can most effectively move the each respect reform .
This is because ,in order to support drug treatment, is the current doctor incentive distortion maximum performance ,,particularly Medicare extended surface standard ,drug costs have increased rapidly ,doudoune moncler,but also keep an addition of the drug to the hole, the hospital has a variety of approaches to push up the cost of drugs .
The basic drug system ,,is more than zero slip ,is out of the water circulation of drugs ,.&nbsp  ;&mdash  ;&mdash  ;essential medicine system in China also assuming drive pharmaceutical industry integration function .
There are thousands of drug production and circulation enterprises ,small scale ,difficult to superintend ,R & D and weak international competitiveness ,moncler,must take structural adjustment ,industry integration path .
Basic medicine system unified procurement ,it is with market means to promote the pharmaceutical industry integration of the effective approach .In the process of integration, there must be some weak competitiveness ,the small size of the out of business ,it is the inevitable requirement of market economy .
&nbsp  ;&mdash ,moncler;&mdash  ;essential drugs system involving huge vested interest .Long-term since ,our country has already formed a parasitic in drug circulation industry chain of vested interest ,execute basic drug bidding and purchasing ,moncler,one part enterprise ,circulation as well as part of the medical staff benefits are subject to damage, it also increased the difficulty of reform .
&nbsp  ;according to this complexity ,Li Ling suggested  : one is to adhere to the direction ,policy stability .Reform to capture main contradiction and contradictory main field .Since the implementation of essential drug system problems ,in addition to work does not reach the designated position ,reform progress is lopsided ,mainly because of the old system of essential drugs this new system can not adapt to the .
Is not the basic drug system itself problem orientation ,but the basic drug system the inherent contradictions exposed .For example ,some drug supply, either because the production and distribution enterprise scope is too little ,either because of a few enterprises with monopoly status does not accept the tender ,moncler pas cher,the need to further deepen reform to solve .
&nbsp  ;two is to improve the basic drug system .Optimization of bidding mechanism ,doudoune moncler,the real implementation of &ldquo ,abercrombie;quantity price linked to &rdquo ,encourage the pharmaceutical industry  ;structural adjustment .
The expansion of basic drug bidding scope ,like some provinces ,public hospital use of essential drugs are also incorporated into the scope of bidding ,abercrombie france,for some small amount of special drugs ,execute unified national provincial joint bidding or bidding .
On some exclusive monopoly drugs and low cost of commonly used drugs ,in terms of price and quantity stability after the introduction of the enterprise fixed-point production .&nbsp  ;three is as soon as possible to promote the county hospital reform .
The current system of essential drugs and basic health care in some cases ,is an important cause of county hospital is not completed, the county hospital reform is completed ,will expand drug tender procurement scope, build smooth county between referral mechanism ,but also conducive to the new rural cooperative medical reimbursement directory and essential drugs list docking .
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