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Businessagency on March 20th news editor true church events for many Chinese first learned about the extract bear bile industry ,and this line of business should be listed for the first time to become a universal topic .
&nbsp ;argumentative focus from whether to maintain the special status of traditional Chinese medicine ,,to should establish what kind of animal protection ,to western medicine conspiracy theory etc.
,moncler pas cher.&nbsp ;the Securities Times reporter investigates the discovery ,bear the effective components of ursodeoxycholic acid production is not monopoly of foreign companies ,domestic ursodeoxycholic acid are but embarrassed : on the one hand is the traditional Chinese medicine in China ingrained ursodeoxycholic acid price on the low side ,a narrow ;on the other hand is foreign pharmaceutical companies in the domestic market to obtain higher pricing at the same time ,the bulk purchase of domestic digest cheap raw materials .
Put aside to extract bear bile moral judgment and medicine quality evaluation, homebred ursodeoxycholic acid how to walk out of predicament is perhaps more urgent problems at present .&nbsp ;Qingdao Star Trading International Trade Limited company boss Liu Xinan is a busy man, March 14th early in the morning he flew from Qingdao to Beijing with a business partner .
The meeting place is chosen in BeiJing Capital Airport ,after talking about things ,he was flying from Beijing to Qingdao .By 7 p.m., the Securities Times reporter dials his telephone .&nbsp ;&ldquo ;domestic ursodeoxycholic acid production has 10 years of history .
&rdquo ;spoke to Liu Xinan full of air ,can the date line 1500 kilometers tired .Liu Xin of ursodeoxycholic acid is western medicine confirmed in bear bile is the main active ingredient ,at present by Qingdao monthly star export to foreign ursodeoxycholic acid is about 3 tons ,while the domestic pharmaceutical production approval and certification through the national GMP manufacturers ursodeoxycholic acid is about 4,.
5 tons per month .&nbsp ;compared with ursodeoxycholic acid ,Chinese people are more familiar with the bear .Bear bile ,strictly refers to black or brown bear gallbladder ,,TCM believes that it can be heat-clearing and detoxifying ,Mingmu ,antispasmodic ,in Chinese medicine application, bear as a drug ,has been for thousands of years .
With high medicinal value ,kill the bear bile once caused Asian wild bear declines .On 1988, Ministry of Health issued on the order of &ldquo ;drainage bear gall &rdquo ;Interim Measures for the administration of the notice ,,make artificial draining bear bile dry goods can be used as natural bear alternative medicine, and temporarily named &ldquo ;&rdquo ,bear bile powder ;to distinguish it from natural bear gall .
&nbsp ;thereafter ,including the true church ,extract bear bile enterprise vigorous development .According to the China Association of traditional Chinese medicine ,said Fang Shuting ,currently a total of 68 legitimate bear farms ,quantity of amount of livestock on hand exceeds 10000, the desirable bear the amount is about 6000 to 8000 .
Although the true church in the size of the bear farms industry is not the biggest, but the first attempt to land do poineering work board extract bear bile enterprises .&nbsp ;coincidentally ,the largest domestic ursodeoxycholic acid pharmaceutical raw materials producers Braun Zhongshan biological technology limited company founder Zhang Heping gem with some sources .
On 2001, Zhang Heping from a Shenzhen pharmaceutical enterprises to join a Vc firms ,as the pharmaceutical industry investment manager ,want to finance capital identity into gem gold tide ,but then the gem launch conditions are not ripe .
In 2004, Zhang Heping left the investment company ,initiated the establishment of the Zhongshan lark biological technology limited company ,ursodeoxycholic acid is one of the main products of the company .
In 2005, Zhongshan Braun was the cornerstone of Shenzhen venture capital Cci Capital Ltd about 3000000 yuan ,now ,Zhongshan Braun has occupied the domestic ursodeoxycholic acid into nearly six market share ,.
&nbsp ;ursodeoxycholic acid UDCA ,1927 by the Japanese first from Chinese gall bladders were isolated in 1937 to determine its structure ,crystallization ,1957 was closed loading JP ,Western Medicine concluded that ursodeoxycholic acid is the most effective composition of bear gall .
In our country, subject to the drug pricing policy ,consumption habits and approved by the state of ursodeoxycholic acid in the range of indications and other factors, ursodeoxycholic acid in the domestic preparation very low prices ,market space is very narrow .
At the same time ,the market has also been overseas preparation plant sexy beast ,michael kors outlet,domestic ursodeoxycholic acid industry live the current situation is rather embarrassing .&nbsp ;&nbsp product spreads tens of times ;ursodeoxycholic acid industry scale is 210000000 &nbsp ;poultry bile is domestic manufacturer producing ursodeoxycholic acid is the main raw material ,the monthly output of about 2000 tons of poultry bile .
Making method includes poultry bile into bile paste ,extracted ursodeoxycholic acid is the main raw material of chenodeoxycholic acid ,followed by a change of chenodeoxycholic acid molecular structure made of ursodeoxycholic acid .
&nbsp ;Zhang Heping to reporters just a dead ,&ldquo ;1 tons of poultry bile can be made about 20 kg of chenodeoxycholic acid ,and further to about 15 kg of ursodeoxycholic acid .Now 1 tons of raw materials is about 12000 yuan ,so doing ,ursodeoxycholic acid is the main raw material for poultry bile a cost about 900 yuan / kg .
Considering the other raw material cost ,manufacturing cost ,management cost and small profits ,ursodeoxycholic acid market price is about 2400 yuan / kg .&rdquo ;and understand according to the reporter to the data ,the extract bear bile method to obtain high quality of bear bile powder market price of about 5000 yuan to 8000 yuan / kg .
Therefore ,according to the unit price ,formed between 2 to 3 times the price .&nbsp ;further specific to the drug material downstream of the preparation link, extract bear bile and bear bile powder ursodeoxycholic acid raw material price is more obvious .
As a result of ursodeoxycholic acid preparations have been included in the basic drug list ,moncler,price is determined by the state ,currently on the market mainstream of ursodeoxycholic acid preparation by effective component of ursodeoxycholic acid in calculation ,the retail price of about 6 yuan per gram .
In contrast ,in order to extract bear bile production of bear gall powder in the consumer market sales price of about 120 yuan per gram .According to the Pharmacopoeia ,bear bile powder taurine ursodeoxycholic acid content is greater than 30% ,converted to ursodeoxycholic acid content is approximately 25% .
If ursodeoxycholic acid the effective components of computing ,terminal bear bile powder products of ursodeoxycholic acid price over 400 yuan per gram .Obviously, to the effective component to measure the western medicine and Chinese traditional medicine of ursodeoxycholic acid preparation of bear bile powder price gap of up to tens of times .
&nbsp ;not only that ,even if only in the western context ,because the country is right of import and domestic drug pricing in different ways ,imported products than the domestic ursodeoxycholic acid preparation to higher prices many times .
Reporters access to data, the import of ursodeoxycholic acid preparation mainly from Germany ,Italy and South Korea ,manufacturers including German Fokker big pharma ,Italy Besty pharmaceutical and Korean bear Pharmaceutical Co Ltd .
Also in accordance with the active ingredient is calculated, the imported ursodeoxycholic acid per gram of unit in 40 to 60 yuan range of fluctuations .&nbsp ;Zhang Heping, former domestic production of ursodeoxycholic acid raw materials on quality of similar foreign products and the existence of small gap ,abercrombie france,but in recent years ,the domestic production of ursodeoxycholic acid raw material quality has made breakthrough progress ,Zhongshan bailing production of ursodeoxycholic acid has not only with the Chinese Pharmacopoeia standards ,but also in line with Europe and the United States and Japan market requirement .
Therefore ,domestic and foreign agents preparation the huge price difference is not derived from the quality gap ,mainly derived from the brand gap and domestic pricing mechanism .&nbsp ,moncler;at low prices at the same time ,moncler,ursodeoxycholic acid and its preparation industry scale is not big .
At present, domestic ursodeoxycholic acid annual capacity of about 100 tons ,the actual output is only around 50 tons ,according to 2400 yuan / kg of market prices ,the total size of about 120000000 yuan .
Plus domestic downstream agents manufacturers ,according to the annual procurement of 15 tons of ursodeoxycholic acid ,preparation market size also is 90000000 yuan only ,the two together ,ursodeoxycholic acid industry overall sales in the domestic income of only 210000000 yuan .
This volume relative to extract bear bile industry ,may be just a drop in the bucket .Data shows ,China now has 68 domestic enterprises to bear ,abercrombie,123 kinds of proprietary Chinese medicine products ,183 downstream enterprises ,the bear farming industry output value reached about 10000000000 yuan .
Even if Shanghai Kai ( 300039) a company ,to bear bile powder as the main raw materials of Tanreqing Injection in the first half of 2011 to obtain business income 390000000 yuan .Visible home ursodeoxycholic acid in the entire industry sales revenue only and Shanghai Kai Bao a product 1/4 .
&nbsp ;domestic market to restrict multiple &nbsp ;overseas preparation plant or into a big winner &nbsp ;low price theory should contribute to the product demand ,but the actual situation is not so .
Shanghai Heng Mountain Pharmaceutical Company Limited is the National more than 30 with ursodeoxycholic acid preparation approval of one of the manufacturers ,but due to weak demand, the current production of ursodeoxycholic acid preparation manufacturers only about 10 .
&nbsp ;Shanghai Heng Mountain production director Zhu Wenjie told the reporters :&ldquo ;the actual situation now is ,in order to support drug treatment, the phenomenon is still very common .
In this case ,the low price drugs opens the market very hard .Sometimes even the bid, the hospital did not buy .Although this is a good product ,but demand has been to go up not to go ,now insist on the production of about 10 enterprises,abercrombie france, only barely production this variety of manufacturers ,because the quantity is too small, simply raise not vivid enterprise .
&rdquo ;&nbsp ,doudoune moncler;but the extract bear bile downstream bear bile powder preparation industry and imported products ,can obtain higher pricing .Zhu Wenjie said :&ldquo ;traditional Chinese medicine prices are relatively high ,demand is relative bigger reason is long-term since drug habits .
Now the hepatobiliary drugs mainly the domestic medicine, and traditional Chinese medicine emphasizes the purity of raw materials ,long-term culture and culture cause consumers favor extract bear bile products .
In addition ,herbal products pricing transparency than western medicine ,traditional Chinese medicine products because of high prices, is more prone to seize the hospital channel .The high price of imported formulations ,by hospital channel favor ,this compression of ursodeoxycholic acid preparation living space .
&rdquo ;&nbsp ;apparently ,domestic ursodeoxycholic acid and its preparation industry faces a price to go up not to go ,also put out of embarrassment .In the preparation of short-term inside cannot break through the bottleneck case ,ursodeoxycholic acid raw material medicine enterprises choose the export market .
Last year, countrywide ursodeoxycholic acid production is 50 tons ,domestic consumption is only 15 tons ,the rest are all exported to foreign .Liu Xinan tells a reporter :&nbsp ;&ldquo ;at present the domestic market of ursodeoxycholic acid demand less ,so that price may offer some exports ,export about 2200 yuan / kg look ,now the overseas mainstream market price is about $360 to $400 / kg .
So from the Chinese market imports of ursodeoxycholic acid ,price may be lower than in similar overseas cheap $50 to $100 / kg .&rdquo ;&nbsp ;Liu Xinan forecast ,abercrombie,in recent years our country of ursodeoxycholic acid in the export volume will be further growth ,with annual export 85 tons of ursodeoxycholic acid ,every kilogram cheap at $50 ,imports from China of ursodeoxycholic acid for overseas manufacturers to annual savings of more than 25000000 yuan .
It is understood ,in overseas ursodeoxycholic acid preparation product profit is relatively high ,from the domestic exports of ursodeoxycholic acid raw materials in overseas only 30% remaining for the pharmaceutical ,used in the manufacture of health care products ,but the production of drugs out to create profit almost health products and quite .
Preparation of high profit imported phenomena are likely to appear in the domestic large-scale .Public data shows ,Korea bear about Korea has about 90% of ursodeoxycholic acid market .Understand according to the reporter ,South Korea bear has applied for Chinese drug regulatory departments located the Korean factory certification ,once certified, Korea bear of ursodeoxycholic acid preparations will be large-scale enter home .
&nbsp ;according to Liu Xinan ,is currently South Korea has more than 60% of the raw materials of chenodeoxycholic acid from Chinese imports .The data shows ,the future overseas manufacturers will be through a large number of cheap imported raw materials in China ,,the mainland after processing Fanxiao Chinese market ,raw material price is exactly the same Chinese products dozens of times over .
In fact ,ursodeoxycholic acid preparation drug imports in the domestic market share is very high .2011, countrywide ursodeoxycholic acid formulation corresponding ursodeoxycholic acid active ingredient consumption is 30 tons ,of which 15 tons of domestic manufacturers use .
That is to say ,in terms of the number of imported drugs occupy nearly half the market price ;and because of the huge gap, in sales in more than 90% of the market by import agents occupy ,doudoune moncler pas cher.
With the domestic ursodeoxycholic acid raw materials enterprises to domestic demand expansion ,preparations continued sluggish and imported products to speed up to enter the domestic market rate ,the future of ursodeoxycholic acid preparation will likely lose domestic ursodeoxycholic acid Market initiative .
&nbsp ;long xiongtu road in He Fang ?&nbsp ;although ursodeoxycholic acid as raw material and preparation in the domestic situation is awkward, but those within the sector in the future full of imagination .
Data shows ,the world of ursodeoxycholic acid in the annual demand of about 1000 tons ,each year about 15% growth .Although the Japanese population is much smaller than that of China ,but Japan consumption of ursodeoxycholic acid up to 300 tons ,the annual consumption of ursodeoxycholic acid in South Korea is also up to 100 tons of above .
&nbsp ;cornerstone venture currently holds a 22% stake in Zhongshan lark ,and the presence of directors .Partner ,President Wang Qiwen said in an interview :&ldquo ;we help Zhongshan lark and solve some poultry bile supply problems,moncler, Zhongshan Braun plan 2012 capacity doubled again, next we hope to the preparation of extension .
&rdquo ;&nbsp ;and the foundation of venture capital is similar ,many industry insiders also optimistic about the future hope of ursodeoxycholic acid has made great development .Liu Xinan told the reporters :&ldquo ;I believe it will replace extract bear bile ,traditional Chinese medicine experts may think this thing is not authentic, that cannot be substituted ,but from a therapeutic perspective, there is no doubt that can completely replace .
&rdquo ;&nbsp ,doudoune moncler;but objectively speaking ,ursodeoxycholic acid problem facing the industry is still very grim .One of them is the national price is low ,difficult to obtain hospital channel support .
Zhu Wenjie said :&ldquo ;the main problem is national price is too low ,Chinese medicine effective constituents of traditional Chinese medicine and Western medicine is the same ,but due to different system ,,two kinds of drug price gap is big .
And now for a dosage form to raise the price of the method is not very strict ,state regulation .&rdquo ;&nbsp ;in addition to change the dosage form ,containing the new drug R & D ursodeoxycholic acid is also a theoretical approach ,because the drug can often get the pricing mechanism of the tilt ,make production enterprises better benefits .
But for using ursodeoxycholic acid and other ingredients together the preparation of artificial bear bile powder to replace natural bear bile powder ,in Zhang Heping ,the need to do a lot of research ,but the fund and time devoted to current industry of any enterprise is unable to assume ,by individual enterprises do not reality .
&nbsp ;another aspect is the drug marketing .Chinese medicine of bear bile powder by the preservation of culture and tradition which is widely accepted by the patients ,but the ursodeoxycholic acid for many consumers are strange .
The cause of this situation is one of the main reasons for domestic ursodeoxycholic acid preparations in the domestic sales are generally use the name rather than the name of commodity ,preparations are not willing to invest substantial resources to promote .
In addition to the entire industry was on a small scale ,single enterprise is difficult to come up with a large funds for marketing .&nbsp ;the extract bear bile downstream of the injection, 2004 product market sales of 17000000 yuan, with 2 years of time only achieved 200000000 yuan sales income .
&nbsp ;in an interview with reporters in the process, regardless of dosage form manufacturers ,traders ,pharmaceutical raw materials producers and venture capital are specifically mentioned the necessity to strengthen the drug marketing .
But they need to face will be long-term since patients consumption habits ,the traditional Chinese medicine culture puissant nick .It will again be involved in learning whether the listing hall ,biochemical synthesis should replace extract bear bile sensitive topics .
&nbsp ;be in a nice hobble to the situation ,Zhu Wenjie said :&ldquo ;wait for the state to ursodeoxycholic acid price is not possible, we expect the country continues to advance reform ,ban drug-maiataining-medicine ,so that in the vast rural market ,ursodeoxycholic acid has a chance .
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+== a  narrow ==
+Businessagency on March 20th  news  editor  true  church  events  for many  Chinese  first learned about the  extract bear bile  industry  ,and this  line of business  should be  listed  for the first time  to become a  universal  topic  .<br>&nbsp  ;argumentative focus  from whether to  maintain  the special status  of traditional Chinese medicine  ,,to  should establish what kind of  animal protection  ,to western  medicine  conspiracy  theory etc.<br>  ,moncler pas cher.&nbsp  ;the Securities Times  reporter investigates the discovery  ,bear  the  effective components  of ursodeoxycholic acid  production  is not  monopoly of foreign companies  ,domestic  ursodeoxycholic acid  are but  embarrassed  : on the one hand is  the  traditional Chinese medicine  in China  ingrained  ursodeoxycholic acid  price on the low side  ,a  narrow  ;on the other hand  is  foreign  pharmaceutical companies  in the domestic market  to obtain higher  pricing  at the same time  ,the bulk purchase of  domestic  digest  cheap raw materials  .<br>Put aside to  extract bear bile  moral judgment  and  medicine  quality  evaluation,  homebred  ursodeoxycholic acid  how to walk out of predicament  is perhaps  more urgent  problems  at present  .&nbsp  ;Qingdao  Star  Trading  International Trade Limited company  boss  Liu Xinan  is a busy man,  March 14th  early in the morning  he  flew from Qingdao to  Beijing with a  business partner  .<br>The meeting place  is chosen in  BeiJing Capital Airport  ,after talking about  things  ,he  was  flying from Beijing to  Qingdao  .By 7 p.m.,  the Securities Times  reporter dials  his telephone  .&nbsp  ;&ldquo  ;domestic  ursodeoxycholic acid  production  has  10 years of history  .<br>&rdquo  ;spoke to Liu Xinan  full of air  ,can  the date line  1500 kilometers  tired  .Liu  Xin  of  ursodeoxycholic acid is  western medicine  confirmed  in bear bile  is the main active ingredient  ,at present  by  Qingdao  monthly  star  export to foreign  ursodeoxycholic acid  is about 3 tons  ,while the domestic  pharmaceutical production  approval  and  certification through the national GMP  manufacturers  ursodeoxycholic acid  is  about 4,.<br>5 tons  per month  .&nbsp  ;compared with  ursodeoxycholic acid  ,Chinese people  are more familiar with  the bear  .Bear bile  ,strictly  refers to  black  or  brown bear  gallbladder  ,,TCM believes that  it  can be heat-clearing and detoxifying  ,Mingmu  ,antispasmodic  ,in Chinese medicine  application,  bear  as  a  drug  ,has been for thousands of years  .<br>With  high medicinal value  ,kill  the bear  bile  once caused  Asian  wild  bear  declines  .On 1988,  Ministry of Health issued    on the  order of &ldquo  ;drainage bear gall  &rdquo  ;Interim Measures for the administration of the  notice    ,,make artificial  draining bear bile  dry goods  can be  used as natural  bear  alternative  medicine,  and temporarily  named &ldquo  ;&rdquo  ,bear bile powder  ;to distinguish it from  natural bear gall  .<br>&nbsp  ;thereafter  ,including the  true  church  ,extract bear bile  enterprise vigorous  development  .According to the  China Association of traditional Chinese medicine  ,said Fang Shuting  ,currently  a total of 68  legitimate  bear farms  ,quantity of amount of livestock on hand  exceeds 10000,  the desirable  bear  the amount is about 6000  to 8000  .<br>Although the  true  church  in the size of the  bear farms  industry  is not  the biggest,  but the first  attempt to  land do poineering work  board  extract bear bile  enterprises  .&nbsp  ;coincidentally  ,the largest domestic  ursodeoxycholic acid  pharmaceutical raw materials producers  Braun Zhongshan  biological technology limited company  founder Zhang Heping  gem with  some sources  .<br>On 2001,  Zhang Heping from  a Shenzhen  pharmaceutical  enterprises to join  a Vc firms  ,as  the pharmaceutical industry  investment  manager  ,want  to finance capital  identity  into  gem  gold  tide  ,but then the  gem launch  conditions are not ripe  .<br>In 2004,  Zhang Heping left the  investment company  ,initiated the establishment of  the Zhongshan lark  biological technology limited company  ,ursodeoxycholic acid is  one of the main products of  the  company  .<br>In 2005,  Zhongshan Braun  was  the cornerstone of Shenzhen  venture  capital  Cci Capital Ltd  about 3000000 yuan  ,now  ,Zhongshan Braun  has occupied the  domestic  ursodeoxycholic acid  into nearly six  market share  ,.<br>&nbsp  ;ursodeoxycholic acid  UDCA  ,1927 by the  Japanese  first from  Chinese  gall bladders  were isolated in  1937  to determine its  structure  ,crystallization  ,1957 was  closed loading  JP  ,Western Medicine  concluded that  ursodeoxycholic acid is  the most  effective  composition of  bear gall  .<br>In our country,  subject to the  drug pricing policy  ,consumption habits and  approved by the state of  ursodeoxycholic acid in  the range of indications  and other factors,  ursodeoxycholic acid in the  domestic preparation  very low prices  ,market  space is very narrow  .<br>At the same time  ,the  market  has also been  overseas  preparation plant  sexy beast  ,michael kors outlet,domestic  ursodeoxycholic acid  industry live the current situation  is rather embarrassing  .&nbsp  ;&nbsp  product  spreads  tens of times  ;ursodeoxycholic acid  industry scale  is  210000000 &nbsp  ;poultry  bile  is domestic manufacturer  producing  ursodeoxycholic acid  is the main raw material  ,the  monthly  output  of  about 2000  tons  of poultry  bile  .<br>Making method includes  poultry  bile  into  bile paste  ,extracted  ursodeoxycholic acid  is the main raw material  of chenodeoxycholic acid  ,followed by a  change  of chenodeoxycholic acid  molecular  structure made of  ursodeoxycholic acid  .<br>&nbsp  ;Zhang Heping to reporters just a dead  ,&ldquo  ;1  tons of  poultry  bile  can be made  about  20 kg of  chenodeoxycholic acid  ,and further  to  about 15 kg of  ursodeoxycholic acid  .Now 1  tons of raw materials  is about 12000 yuan  ,so doing  ,ursodeoxycholic acid  is the main raw material for  poultry  bile  a  cost  about 900 yuan /  kg  .<br>Considering the other  raw material cost  ,manufacturing  cost  ,management  cost  and small  profits  ,ursodeoxycholic acid  market  price is about 2400 yuan /  kg  .&rdquo  ;and understand according to the reporter  to the data  ,the  extract bear bile  method to obtain  high quality  of bear bile powder  market price of about 5000  yuan to 8000 yuan /  kg  .<br>Therefore  ,according to the  unit  price  ,formed between  2  to 3 times the  price  .&nbsp  ;further  specific to the  drug material  downstream of the  preparation  link,  extract bear bile  and  bear bile powder  ursodeoxycholic acid  raw material  price  is more obvious  .<br>As a result of  ursodeoxycholic acid  preparations have been  included in the basic  drug list  ,moncler,price is  determined by the state  ,currently on the market  mainstream  of ursodeoxycholic acid  preparation  by  effective component  of ursodeoxycholic acid in  calculation  ,the retail price  of about  6  yuan  per gram  .<br>In contrast  ,in order to  extract bear bile  production of  bear gall powder  in the consumer market  sales  price of about  120  yuan  per gram  .According to the  Pharmacopoeia  ,bear bile powder  taurine  ursodeoxycholic acid  content is  greater than 30%  ,converted to  ursodeoxycholic acid  content is approximately 25%  .<br>If  ursodeoxycholic acid  the  effective components of  computing  ,terminal  bear bile powder  products  of ursodeoxycholic acid  price over  400 yuan per gram  .Obviously,  to the  effective component  to measure the  western medicine  and Chinese traditional medicine  of ursodeoxycholic acid  preparation  of bear bile powder  price  gap of up to  tens of times  .<br>&nbsp  ;not only that  ,even if only  in the  western  context  ,because the country is right  of import and domestic  drug pricing  in different ways  ,imported products  than the domestic  ursodeoxycholic acid  preparation  to higher prices  many times  .<br>Reporters access to  data,  the import  of ursodeoxycholic acid  preparation mainly  from Germany  ,Italy and South Korea  ,manufacturers  including  German Fokker  big pharma  ,Italy Besty  pharmaceutical  and Korean  bear  Pharmaceutical Co Ltd  .<br>Also in accordance with  the active ingredient  is calculated,  the  imported  ursodeoxycholic acid  per gram of  unit in 40  to 60  yuan  range of fluctuations  .&nbsp  ;Zhang Heping,  former domestic  production  of ursodeoxycholic acid  raw materials  on quality  of similar foreign products and the  existence of small gap  ,abercrombie france,but in recent  years  ,the domestic production  of ursodeoxycholic acid  raw material  quality has  made breakthrough progress  ,Zhongshan bailing  production  of ursodeoxycholic acid  has not only  with the Chinese Pharmacopoeia standards  ,but also in line with  Europe and the United States and Japan  market  requirement  .<br>Therefore  ,domestic  and foreign  agents  preparation  the huge price  difference is not  derived from the  quality gap  ,mainly  derived from the  brand  gap  and domestic  pricing  mechanism  .&nbsp  ,moncler;at low prices  at the same time  ,moncler,ursodeoxycholic acid  and its  preparation industry  scale  is not  big  .<br>At present,  domestic  ursodeoxycholic acid  annual capacity of about 100  tons  ,the actual output  is only around 50 tons  ,according to 2400 yuan /  kg of  market prices  ,the total  size of about 120000000  yuan  .<br>Plus domestic  downstream  agents  manufacturers  ,according to the  annual  procurement of 15 tons of  ursodeoxycholic acid  ,preparation market  size also  is 90000000 yuan only  ,the two together  ,ursodeoxycholic acid  industry overall  sales in the domestic  income  of only 210000000 yuan  .<br>This  volume  relative to  extract bear bile  industry  ,may be just  a drop in the bucket  .Data shows  ,China now has 68  domestic  enterprises  to  bear  ,abercrombie,123 kinds of  proprietary Chinese medicine  products  ,183  downstream enterprises  ,the  bear farming  industry output value  reached about 10000000000 yuan  .<br>Even if Shanghai  Kai  (  300039)  a company  ,to  bear bile powder  as the main raw materials of  Tanreqing Injection  in the first half of 2011  to obtain  business income 390000000 yuan  .Visible home  ursodeoxycholic acid in  the entire industry  sales revenue only  and  Shanghai Kai Bao  a  product  1/4  .<br>&nbsp  ;domestic  market to restrict  multiple &nbsp  ;overseas  preparation plant  or into a  big winner  &nbsp  ;low price  theory should  contribute to the  product  demand  ,but  the actual situation is  not  so  .<br>Shanghai  Heng Mountain Pharmaceutical  Company Limited  is  the National more than 30  with  ursodeoxycholic acid  preparation  approval  of one of the manufacturers  ,but  due to weak demand,  the current  production of ursodeoxycholic acid  preparation  manufacturers  only  about 10  .<br>&nbsp  ;Shanghai  Heng Mountain  production director  Zhu Wenjie told the reporters  :&ldquo  ;the actual situation now  is  ,in order to support drug treatment,  the  phenomenon is still very  common  .<br>In this case  ,the low  price drugs  opens the market very hard  .Sometimes  even  the bid,  the hospital  did not  buy  .Although this  is a good product  ,but  demand has been  to go up not to go  ,now insist on the  production of  about 10  enterprises,abercrombie france,  only barely  production  this variety of  manufacturers  ,because the  quantity is too small,  simply  raise not vivid  enterprise  .<br>&rdquo  ;&nbsp  ,doudoune moncler;but  the  extract bear bile  downstream  bear bile powder  preparation industry  and imported  products  ,can  obtain higher  pricing  .Zhu Wenjie said  :&ldquo  ;traditional Chinese medicine  prices are relatively high  ,demand is relative bigger  reason  is long-term since  drug habits  .<br>Now the  hepatobiliary  drugs  mainly the domestic  medicine,  and traditional Chinese medicine  emphasizes  the purity of  raw materials  ,long-term  culture  and culture  cause  consumers favor  extract bear bile  products  .<br>In addition  ,herbal products  pricing transparency  than  western medicine  ,traditional Chinese medicine  products  because of high prices,  is more prone to  seize the  hospital channel  .The high price of  imported  formulations  ,by hospital  channel  favor  ,this  compression  of  ursodeoxycholic acid  preparation  living space  .<br>&rdquo  ;&nbsp  ;apparently  ,domestic  ursodeoxycholic acid  and its preparation  industry faces a  price  to go up not to go  ,also  put  out of  embarrassment  .In the preparation of  short-term inside cannot  break through the bottleneck  case  ,ursodeoxycholic acid  raw material medicine  enterprises choose the  export market  .<br>Last year,  countrywide  ursodeoxycholic acid  production is 50  tons  ,domestic consumption  is only 15  tons  ,the rest  are all exported to foreign  .Liu Xinan tells a reporter  :&nbsp  ;&ldquo  ;at present  the domestic market  of ursodeoxycholic acid  demand less  ,so that  price may  offer  some  exports  ,export  about 2200 yuan /  kg  look  ,now  the overseas mainstream market  price  is about $360  to  $400  / kg  .<br>So from the  Chinese  market imports of  ursodeoxycholic acid  ,price may be lower than  in  similar overseas  cheap $50  to  $100  / kg  .&rdquo  ;&nbsp  ;Liu Xinan forecast  ,abercrombie,in recent years  our country  of ursodeoxycholic acid in the  export volume will be further  growth  ,with annual  export 85 tons of  ursodeoxycholic acid  ,every kilogram  cheap  at $50  ,imports from China of  ursodeoxycholic acid  for  overseas manufacturers to  annual savings  of more than 25000000  yuan  .<br>It is understood  ,in  overseas  ursodeoxycholic acid  preparation  product  profit is relatively high  ,from the domestic exports  of ursodeoxycholic acid  raw materials  in  overseas  only 30%  remaining  for the pharmaceutical  ,used in the manufacture of  health care products  ,but the production of  drugs out  to create  profit almost  health products and  quite  .<br>Preparation of  high profit  imported  phenomena are likely to  appear  in the domestic large-scale  .Public data shows  ,Korea  bear  about  Korea has  about 90% of  ursodeoxycholic acid  market  .Understand according to the reporter  ,South Korea  bear  has applied for  Chinese  drug regulatory departments  located the  Korean  factory  certification  ,once certified,  Korea  bear  of ursodeoxycholic acid  preparations  will be  large-scale  enter home  .<br>&nbsp  ;according to Liu Xinan  ,is currently  South Korea  has more than 60% of the  raw materials  of chenodeoxycholic acid  from  Chinese  imports  .The data shows  ,the future  overseas manufacturers  will be  through a large number of  cheap imported  raw materials in China  ,,the  mainland  after processing  Fanxiao  Chinese  market  ,raw material  price  is  exactly the same  Chinese  products  dozens of  times over  .<br>In fact  ,ursodeoxycholic acid  preparation  drug imports  in the domestic market share  is very high  .2011,  countrywide  ursodeoxycholic acid  formulation  corresponding  ursodeoxycholic acid  active ingredient  consumption is 30  tons  ,of which  15 tons of  domestic manufacturers  use  .<br>That is to say  ,in terms of the number of  imported  drugs  occupy  nearly half  the market  price  ;and because of  the huge gap,  in sales  in more than 90% of the  market by  import  agents  occupy  ,doudoune moncler pas cher.<br>With the domestic  ursodeoxycholic acid  raw materials  enterprises to  domestic  demand  expansion  ,preparations  continued sluggish  and imported products  to speed up  to enter the domestic market  rate  ,the future  of ursodeoxycholic acid  preparation  will likely  lose  domestic  ursodeoxycholic acid  Market initiative  .<br>&nbsp  ;long  xiongtu  road in He Fang  ?&nbsp  ;although  ursodeoxycholic acid as  raw material and preparation in  the domestic  situation is awkward,  but  those within the sector  in the future  full of imagination  .<br>Data shows  ,the world  of  ursodeoxycholic acid in the  annual demand  of about 1000 tons  ,each year  about 15% growth  .Although the  Japanese population  is  much smaller than that of China  ,but  Japan  consumption  of ursodeoxycholic acid  up to 300  tons  ,the annual consumption of  ursodeoxycholic acid  in South Korea  is also up to 100  tons of above  .<br>&nbsp  ;cornerstone  venture  currently holds a  22% stake in  Zhongshan  lark  ,and the presence of  directors  .Partner  ,President  Wang Qiwen said in an interview  :&ldquo  ;we help  Zhongshan lark  and solve some  poultry  bile  supply problems,moncler,  Zhongshan Braun  plan  2012 capacity  doubled again,  next we  hope  to the preparation of  extension  .<br>&rdquo  ;&nbsp  ;and the foundation of  venture capital    is similar  ,many  industry insiders  also optimistic about the  future  hope  of ursodeoxycholic acid  has  made great development  .Liu Xinan told the reporters  :&ldquo  ;I believe  it will  replace  extract bear bile  ,traditional Chinese medicine experts  may  think this thing  is not  authentic,  that  cannot be substituted  ,but  from a therapeutic  perspective,  there is no doubt that  can completely  replace  .<br>&rdquo  ;&nbsp  ,doudoune moncler;but  objectively speaking  ,ursodeoxycholic acid  problem facing the industry  is still very grim  .One of them is the  national price  is low  ,difficult to obtain  hospital channel  support  .<br>Zhu Wenjie said  :&ldquo  ;the main problem  is national price  is too low  ,Chinese medicine  effective  constituents  of traditional Chinese medicine and Western medicine  is  the same  ,but due to  different  system  ,,two kinds of  drug price  gap is  big  .<br>And now  for  a  dosage form  to  raise the price of the  method is  not  very strict  ,state regulation  .&rdquo  ;&nbsp  ;in addition to  change the  dosage form  ,containing  the  new drug  R & D  ursodeoxycholic acid  is also a  theoretical approach  ,because the  drug  can often  get  the pricing mechanism  of the  tilt  ,make production enterprises  better benefits  .<br>But for  using ursodeoxycholic acid  and  other  ingredients  together  the preparation of artificial  bear bile powder  to  replace natural  bear bile powder  ,in Zhang Heping  ,the  need to  do a lot of research  ,but the  fund and time  devoted to current  industry  of any  enterprise is  unable to assume  ,by  individual enterprises  do  not reality  .<br>&nbsp  ;another aspect  is the  drug marketing  .Chinese medicine  of bear bile powder  by the  preservation of culture and tradition  which is widely  accepted by the patients  ,but the  ursodeoxycholic acid  for many  consumers  are  strange  .<br>The cause of this situation  is one of the main reasons for  domestic  ursodeoxycholic acid  preparations in the domestic  sales  are generally  use  the name  rather than the  name of commodity  ,preparations  are not willing to  invest substantial resources  to promote  .<br>In addition to  the entire industry  was on a small scale  ,single enterprise  is difficult to come up with a  large funds for  marketing  .&nbsp  ;the  extract bear bile  downstream of the  injection,  2004 product  market  sales of 17000000 yuan,  with 2 years of time only  achieved  200000000 yuan sales  income  .<br>&nbsp  ;in an interview with reporters  in the process,  regardless of  dosage form manufacturers  ,traders  ,pharmaceutical raw materials producers  and venture capital  are  specifically mentioned  the necessity  to strengthen the  drug marketing  .<br>But they need to  face will be  long-term since  patients  consumption habits  ,the traditional Chinese medicine  culture puissant  nick  .It will again be  involved in  learning  whether  the  listing  hall  ,biochemical  synthesis  should  replace  extract bear bile  sensitive topics  .<br>&nbsp  ;be in a nice hobble  to  the  situation  ,Zhu Wenjie said  :&ldquo  ;wait for the state  to  ursodeoxycholic acid  price  is not possible,  we expect the  country continues to advance  reform  ,ban  drug-maiataining-medicine  ,so that  in the vast rural market  ,ursodeoxycholic acid  has a chance  .<br>Related articles:
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